Literature DB >> 21228

Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats.

M C Scally, I Ulus, R J Wurtman.   

Abstract

Animals received either haloperidol (2 mg/kg) or probenecid (200 mg/kg) in conjunction with tyrosine (100 mg/kg) or its diluent. Striatal homovanillic acid levels increased in probenecid-treated animals to the same range whether they were given tyrosine or not. In haloperidol-treated animals the levels of homovanillic acid were significantly elevated in animals receiving tyrosine. Tyrosine and homovanillic acid levels were highly correlated as determined by linear regression analysis.

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Year:  1977        PMID： 21228     DOI： 10.1007/BF01252960

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  9 in total

1.  A fluorometric method for the estimation of tyrosine in plasma and tissues.

Authors:  T P WAALKES; S UDENFRIEND
Journal:  J Lab Clin Med       Date:  1957-11

2.  Tyrosine hydroxylase in rat brain--cofactor requirements, regional and subcellular distribution.

Authors:  J T Coyle
Journal:  Biochem Pharmacol       Date:  1972-07-15       Impact factor: 5.858

3.  Assay of tyrosine hydroxylase by coupled decarboxylation of DOPA formed from 1- 14 C-L-tyrosine.

Authors:  J C Waymire; R Bjur; N Weiner
Journal:  Anal Biochem       Date:  1971-10       Impact factor: 3.365

4.  The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicyclic acid and iodide.

Authors:  R Spector; A V Lorenzo
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

5.  Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat.

Authors:  U Ungerstedt; L L Butcher; S G Butcher; N E Andén; K Fuxe
Journal:  Brain Res       Date:  1969-07       Impact factor: 3.252

Review 6.  Control of brain monoamine synthesis by diet and plasma amino acids.

Authors:  R J Wurtman; J D Fernstrom
Journal:  Am J Clin Nutr       Date:  1975-06       Impact factor: 7.045

7.  Changes of kinetic constant of striatal tyrosine hydroxylase elicited by neuroleptics that impair the function of dopamine receptors.

Authors:  B Zivkovic; A Guidotti
Journal:  Brain Res       Date:  1974-10-25       Impact factor: 3.252

8.  Differential drug effects on dopamine concentrations and rates of turnover in the median eminence, olfactory tubercle and corpus striatum.

Authors:  G A Gudelsky; E K Moore
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

9.  Brain catechol synthesis: control by train tyrosine concentration.

Authors:  R J Wurtman; F Larin; S Mostafapour; J D Fernstrom
Journal:  Science       Date:  1974-07-12       Impact factor: 47.728
  9 in total
  19 in total

1.  L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions.

Authors:  Joseph M Breier; Michael G Bankson; Bryan K Yamamoto
Journal:  J Neurosci       Date:  2006-01-04       Impact factor: 6.167

2.  Serotoninergic modulation of mesolimbic and frontal cortical dopamine neurons.

Authors:  P C Waldmeier
Journal:  Experientia       Date:  1980-09-15

3.  Regional tyrosine levels in rat brain after tyrosine administration.

Authors:  M C Morre; F Hefti; R J Wurtman
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

4.  Tyrosine loading enhances catecholamine excretion by rats.

Authors:  R Alonso; J C Agharanya; R J Wurtman
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

5.  Mesocortical dopamine neurons: high basal firing frequency predicts tyrosine dependence of dopamine synthesis.

Authors:  S Y Tam; J D Elsworth; C W Bradberry; R H Roth
Journal:  J Neural Transm Gen Sect       Date:  1990

6.  Plasma tyrosine in normal humans: effects of oral tyrosine and protein-containing meals.

Authors:  E Melamed; B Glaeser; J H Growdon; R J Wurtman
Journal:  J Neural Transm       Date:  1980       Impact factor: 3.575

7.  Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions.

Authors:  E Melamed; F Hefti; R J Wurtman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

8.  In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels.

Authors:  George E Jaskiw; Bobbi Kirkbride; Rodolfo Bongiovanni
Journal:  Psychopharmacology (Berl)       Date:  2006-03-16       Impact factor: 4.530

9.  Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[beta-11C]dopa turnover in the rat striatum with infusion of L-tyrosine.

Authors:  H Tsukada; K J Lindner; P Hartvig; Y Tani; P Bjurling; T Kihlberg; G Westerberg; Y Watanabe; B Långström
Journal:  J Neural Transm Gen Sect       Date:  1994

10.  Tyrosine administration enhances dopamine synthesis and release in light-activated rat retina.

Authors:  C J Gibson; C J Watkins; R J Wurtman
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575
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