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Literature DB >> 21223360

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

Linda Björkhem-Bergman, Jonatan D Lindh, Peter Bergman.

Abstract

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Year: 2011 PMID： 21223360 PMCID： PMC3141200 DOI： 10.1111/j.1365-2125.2011.03907.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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12 in total

1. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.

Authors: Linda Björkhem-Bergman; Jure Acimovic; Ulla-Britta Torndal; Paolo Parini; Lennart C Eriksson
Journal: Anticancer Res Date: 2010-04 Impact factor: 2.480

Review 2. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.

Authors: Mukesh K Jain; Paul M Ridker
Journal: Nat Rev Drug Discov Date: 2005-12 Impact factor: 84.694

3. A simple and sensitive HPLC-UV method for quantitation of lovastatin in human plasma: application to a bioequivalence study.

Authors: Mehrdad Hamidi; Najmeh Zarei; Mohammad-Ali Shahbazi
Journal: Biol Pharm Bull Date: 2009-09 Impact factor: 2.233

4. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.

Authors: De-xiu Bu; Margarite Tarrio; Nir Grabie; Yuzhi Zhang; Hiroyuki Yamazaki; George Stavrakis; Elena Maganto-Garcia; Zachary Pepper-Cunningham; Petr Jarolim; Masanori Aikawa; Guillermo García-Cardeña; Andrew H Lichtman
Journal: J Clin Invest Date: 2010-05-03 Impact factor: 14.808

5. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.

Authors: Karin M Thelen; Katharina M Rentsch; Ursula Gutteck; Maura Heverin; Maria Olin; Ulla Andersson; Arnold von Eckardstein; Ingemar Björkhem; Dieter Lütjohann
Journal: J Pharmacol Exp Ther Date: 2005-11-10 Impact factor: 4.030

6. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Authors: Y Kureishi; Z Luo; I Shiojima; A Bialik; D Fulton; D J Lefer; W C Sessa; K Walsh
Journal: Nat Med Date: 2000-09 Impact factor: 53.440

7. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.

Authors: Sawsan Youssef; Olaf Stüve; Juan C Patarroyo; Pedro J Ruiz; Jennifer L Radosevich; Eun Mi Hur; Manuel Bravo; Dennis J Mitchell; Raymond A Sobel; Lawrence Steinman; Scott S Zamvil
Journal: Nature Date: 2002-11-07 Impact factor: 49.962

8. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

Authors: G Weitz-Schmidt; K Welzenbach; V Brinkmann; T Kamata; J Kallen; C Bruns; S Cottens; Y Takada; U Hommel
Journal: Nat Med Date: 2001-06 Impact factor: 53.440

9. Pharmacodynamics and pharmacokinetic-pharmacodynamic relationships of atorvastatin, an HMG-CoA reductase inhibitor.

Authors: R H Stern; B B Yang; N J Hounslow; M MacMahon; R B Abel; S C Olson
Journal: J Clin Pharmacol Date: 2000-06 Impact factor: 3.126

10. Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.

Authors: Jenni E Keskitalo; Marja K Pasanen; Pertti J Neuvonen; Mikko Niemi
Journal: Pharmacogenomics Date: 2009-10 Impact factor: 2.533

58 in total

1. OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer.

Authors: Biswajit Saha; Tanmay Mathur; Katelyn F Handley; Wei Hu; Vahid Afshar-Kharghan; Anil K Sood; Abhishek Jain
Journal: Blood Adv Date: 2020-07-28

2. Statins influence epithelial expression of the anti-microbial peptide LL-37/hCAP-18 independently of the mevalonate pathway.

Authors: P Lüthje; S Walker; W Kamolvit; S Mohanty; K Pütsep; A Brauner
Journal: Clin Exp Immunol Date: 2018-10-11 Impact factor: 4.330

3. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.

Authors: Kathryn P Trogden; Rachel A Battaglia; Parijat Kabiraj; Victoria J Madden; Harald Herrmann; Natasha T Snider
Journal: FASEB J Date: 2018-01-18 Impact factor: 5.191

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

1. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.

Review 2. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.

3. A simple and sensitive HPLC-UV method for quantitation of lovastatin in human plasma: application to a bioequivalence study.

4. Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.

5. Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.

6. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

7. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.

8. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

9. Pharmacodynamics and pharmacokinetic-pharmacodynamic relationships of atorvastatin, an HMG-CoA reductase inhibitor.

10. Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin.

1. OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer.

2. Statins influence epithelial expression of the anti-microbial peptide LL-37/hCAP-18 independently of the mevalonate pathway.

3. An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.

4. Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases.

5. A time course investigation of the statin paradox among valvular interstitial cell phenotypes.

Review 6. Heme Oxygenases in Cardiovascular Health and Disease.

7. Topical simvastatin promotes healing of Staphylococcus aureus-contaminated cutaneous wounds.

8. Anti-inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials.

Review 9. Innovations in asthma therapy: is there a role for inhaled statins?

10. PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice.