Literature DB >> 21222031

Highly efficient and catalyst-free synthesis of substituted thioureas in water.

Shi-Feng Gan1, Jie-Ping Wan, Yuan-Jiang Pan, Cui-Rong Sun.   

Abstract

A highly efficient and catalyst-free method for the synthesis of substituted thiourea derivatives is presented. The synthesis is performed through the reaction of thiazolidine-2-thiones with various amines in water. A sound number of thioureas with both unsymmetrical and symmetrical architectures have been obtained in good to excellent yields.

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Year:  2011        PMID： 21222031     DOI： 10.1007/s11030-010-9298-6

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  16 in total

1.  Solid-Phase Synthesis of 2-Aminothiazoles.

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Journal:  J Org Chem       Date:  1998-01-09       Impact factor: 4.354

2.  Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.

Authors:  Séamus H McCooey; Stephen J Connon
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3.  A novel three-component one-pot reaction involving alkynes, urea or thiourea, and aldehydes.

Authors:  Shenlin Huang; Yuanjiang Pan; Yulin Zhu; Anxin Wu
Journal:  Org Lett       Date:  2005-08-18       Impact factor: 6.005

4.  A concise synthesis of substituted thiourea derivatives in aqueous medium.

Authors:  Mahagundappa R Maddani; Kandikere R Prabhu
Journal:  J Org Chem       Date:  2010-04-02       Impact factor: 4.354

5.  Metal-free organocatalysis through explicit hydrogen bonding interactions.

Authors:  Peter R Schreiner
Journal:  Chem Soc Rev       Date:  2003-09       Impact factor: 54.564

6.  2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.

Authors:  C Walpole; S Y Ko; M Brown; D Beattie; E Campbell; F Dickenson; S Ewan; G A Hughes; M Lemaire; J Lerpiniere; S Patel; L Urban
Journal:  J Med Chem       Date:  1998-08-13       Impact factor: 7.446

7.  Chemo-/regioselective synthesis of 6-unsubstituted dihydropyrimidinones, 1,3-thiazines and chromones via novel variants of Biginelli reaction.

Authors:  Jie-Ping Wan; Yuan-Jiang Pan
Journal:  Chem Commun (Camb)       Date:  2009-03-30       Impact factor: 6.222

8.  Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions.

Authors:  Angelo Ranise; Andrea Spallarossa; Olga Bruno; Silvia Schenone; Paola Fossa; Giulia Menozzi; Francesco Bondavalli; Luisa Mosti; Annalisa Capuano; Filomena Mazzeo; Giuseppe Falcone; Walter Filippelli
Journal:  Farmaco       Date:  2003-09

9.  Synthesis of dihydrothiophenes or spirocyclic compounds by domino reactions of 1,3-thiazolidinedione.

Authors:  Jing Sun; Li-Li Zhang; Er-Yan Xia; Chao-Guo Yan
Journal:  J Org Chem       Date:  2009-05-01       Impact factor: 4.354

10.  Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other pharmacological properties.

Authors:  A M Omar; A M Farghaly; A A Hazzai; N H Eshba; F M Sharabi; T T Daabees
Journal:  J Pharm Sci       Date:  1981-09       Impact factor: 3.534
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  1 in total

Review 1.  Chiral Thioureas-Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry.

Authors:  Franz Steppeler; Dominika Iwan; Elżbieta Wojaczyńska; Jacek Wojaczyński
Journal:  Molecules       Date:  2020-01-18       Impact factor: 4.411
  1 in total

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