Literature DB >> 19532949

Chemo-/regioselective synthesis of 6-unsubstituted dihydropyrimidinones, 1,3-thiazines and chromones via novel variants of Biginelli reaction.

Jie-Ping Wan1, Yuan-Jiang Pan.   

Abstract

A novel and facile cascade Biginelli-like assembly employing enaminone, aldehyde and urea/thiourea has been developed, which provides a highly chemo- and regioselective synthesis of new dihydropyrimidinones, 1,3-thiazines and chromones by altering particular functional groups in the reactants.

Entities:  

Year:  2009        PMID： 19532949     DOI： 10.1039/b901112a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Highly efficient and catalyst-free synthesis of substituted thioureas in water.

Authors:  Shi-Feng Gan; Jie-Ping Wan; Yuan-Jiang Pan; Cui-Rong Sun
Journal:  Mol Divers       Date:  2011-01-11       Impact factor: 2.943

2.  An Efficient One-Pot Green Protocol for the Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-Ones Using Recyclable Amberlyst 15 DRY as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reaction.

Authors:  Srinivasa Rao Jetti; Divya Verma; Shubha Jain
Journal:  ISRN Org Chem       Date:  2012-10-14

3.  Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea.

Authors:  Jie-Ping Wan; Yunfang Lin; Kaikai Hu; Yunyun Liu
Journal:  Beilstein J Org Chem       Date:  2014-01-29       Impact factor: 2.883

4.  An efficient synthesis of 4,5-diaryl-3,4-dihydropyrimidin-2(1H)-one via a cesium carbonate-promoted direct condensation of 1-aryl-2-propanone with 1,1'-(arylmethylene)diurea.

Authors:  Yi-Cong Guo; Xuan-Di Song; Wei Deng; Weidong Rao; Haiyan Xu; Zhi-Liang Shen
Journal:  RSC Adv       Date:  2020-08-14       Impact factor: 4.036

5.  The construction of fluorophoric thiazolo-[2,3-b]quinazolinone derivatives: a multicomponent domino synthetic approach.

Authors:  Prajna Parimita Mohanta; Hari Narayan Pati; Ajaya Kumar Behera
Journal:  RSC Adv       Date:  2020-04-17       Impact factor: 4.036

6.  Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde.

Authors:  Haijun Qu; Xuejian Li; Fan Mo; Xufeng Lin
Journal:  Beilstein J Org Chem       Date:  2013-12-11       Impact factor: 2.883
  6 in total

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