| Literature DB >> 21220535 |
Jason P Folster1, Gary Pecic, Anna Bowen, Regan Rickert, Alessandra Carattoli, Jean M Whichard.
Abstract
We characterized 20 Shigella isolates with decreased susceptibility to fluoroquinolones. Most patients (80%) from whom a travel history was obtained reported travel to South or Southeast Asia. Mutations within the quinolone resistance determining regions of gyrA and parC and plasmid-mediated resistance determinants (qnrB, qnrS, and aac(6')-Ib-cr) were identified. The rise in antimicrobial resistance among Shigella isolates may necessitate the increased use of extended-spectrum cephalosporins or macrolides in some patients.Entities:
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Year: 2011 PMID: 21220535 PMCID: PMC3067149 DOI: 10.1128/AAC.01463-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191