OBJECTIVES: structural abnormalities in the hippocampus have been implicated in the pathophysiology of major depressive disorder (MDD). The brain-derived neurotrophic factor (BDNF) val66met polymorphism may contribute to these abnormalities and therefore confer vulnerability to MDD. This study examined whether there is a relationship among BDNF genotype, hippocampal volumes, and MDD in older adults. METHODS: thirty-three older adults with MDD and 23 psychiatrically normal comparison subjects were studied. Structural magnetic resonance imaging analysis was used to quantify hippocampal volumes. A repeated-measures analysis of covariance examined the relationships among BDNF val66met (val/val, met carrier), diagnosis (depressed, nondepressed), and hippocampal volumes (right, left). Age, gender, education, and whole brain volume were included as covariates. RESULTS: elderly MDD BDNF val/val homozygotes had significantly higher right hippocampal volumes compared with nondepressed val/val subjects. However, there was no difference between the depressed and healthy nondepressed met carriers. In addition, depressed met carriers had an earlier age of onset of depressive illness than val/val homozygotes, but age of onset did not moderate the relationship between hippocampal volumes and MDD diagnosis. CONCLUSION: these results provide preliminary evidence of a neuroprotective role of the val/val genotype, suggesting that neurotrophic factor production protects against pathophysiological processes triggered by depression in older adults with later age of onset of MDD. The BDNF val66met polymorphism may play a salient role in structural alterations of the hippocampus in older adults with MDD. 2011 American Association for Geriatric Psychiatry.
OBJECTIVES:structural abnormalities in the hippocampus have been implicated in the pathophysiology of major depressive disorder (MDD). The brain-derived neurotrophic factor (BDNF) val66met polymorphism may contribute to these abnormalities and therefore confer vulnerability to MDD. This study examined whether there is a relationship among BDNF genotype, hippocampal volumes, and MDD in older adults. METHODS: thirty-three older adults with MDD and 23 psychiatrically normal comparison subjects were studied. Structural magnetic resonance imaging analysis was used to quantify hippocampal volumes. A repeated-measures analysis of covariance examined the relationships among BDNFval66met (val/val, met carrier), diagnosis (depressed, nondepressed), and hippocampal volumes (right, left). Age, gender, education, and whole brain volume were included as covariates. RESULTS: elderly MDDBDNFval/val homozygotes had significantly higher right hippocampal volumes compared with nondepressed val/val subjects. However, there was no difference between the depressed and healthy nondepressed met carriers. In addition, depressedmet carriers had an earlier age of onset of depressive illness than val/val homozygotes, but age of onset did not moderate the relationship between hippocampal volumes and MDD diagnosis. CONCLUSION: these results provide preliminary evidence of a neuroprotective role of the val/val genotype, suggesting that neurotrophic factor production protects against pathophysiological processes triggered by depression in older adults with later age of onset of MDD. The BDNFval66met polymorphism may play a salient role in structural alterations of the hippocampus in older adults with MDD. 2011 American Association for Geriatric Psychiatry.
Authors: Frank Jessen; Anna Schuhmacher; Ole von Widdern; Vera Guttenthaler; Susanne Hofels; Husam Suliman; Lukas Scheef; Wolfgang Block; Horst Urbach; Wolfgang Maier; Astrid Zobel Journal: Psychiatr Genet Date: 2009-04 Impact factor: 2.458
Authors: L Pezawas; A Meyer-Lindenberg; A L Goldman; B A Verchinski; G Chen; B S Kolachana; M F Egan; V S Mattay; A R Hariri; D R Weinberger Journal: Mol Psychiatry Date: 2008-03-18 Impact factor: 15.992
Authors: Michael F Egan; Masami Kojima; Joseph H Callicott; Terry E Goldberg; Bhaskar S Kolachana; Alessandro Bertolino; Eugene Zaitsev; Bert Gold; David Goldman; Michael Dean; Bai Lu; Daniel R Weinberger Journal: Cell Date: 2003-01-24 Impact factor: 41.582
Authors: Warren D Taylor; Stephan Züchner; Douglas R McQuoid; David C Steffens; Marcy C Speer; K Ranga R Krishnan Journal: Am J Geriatr Psychiatry Date: 2007-10 Impact factor: 4.105
Authors: F Miyajima; W Ollier; A Mayes; A Jackson; N Thacker; P Rabbitt; N Pendleton; M Horan; A Payton Journal: Genes Brain Behav Date: 2007-10-31 Impact factor: 3.449
Authors: Sandra Bell-McGinty; Meryl A Butters; Carolyn Cidis Meltzer; Phil J Greer; Charles F Reynolds; James T Becker Journal: Am J Psychiatry Date: 2002-08 Impact factor: 18.112
Authors: Naftali Raz; Cheryl L Dahle; Karen M Rodrigue; Kristen M Kennedy; Susan J Land; Bradley S Jacobs Journal: Front Hum Neurosci Date: 2008-10-03 Impact factor: 3.169
Authors: J P Hayes; A Reagan; M W Logue; S M Hayes; N Sadeh; D R Miller; M Verfaellie; E J Wolf; R E McGlinchey; W P Milberg; A Stone; S A Schichman; M W Miller Journal: Genes Brain Behav Date: 2017-08-30 Impact factor: 3.449
Authors: Mark J Niciu; Nicolas D Iadarola; Dipavo Banerjee; David A Luckenbaugh; Minkyung Park; Marc Lener; Lawrence Park; Dawn F Ionescu; Elizabeth D Ballard; Nancy E Brutsche; Nirmala Akula; Francis J McMahon; Rodrigo Machado-Vieira; Allison C Nugent; Carlos A Zarate Journal: J Psychopharmacol Date: 2017-10-17 Impact factor: 4.153
Authors: Christopher M Marano; Clifford I Workman; Christopher H Lyman; Cynthia A Munro; Michael A Kraut; Gwenn S Smith Journal: Am J Geriatr Psychiatry Date: 2013-10-05 Impact factor: 4.105