OBJECTIVE: The authors' goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry. METHOD: They used statistical parametric mapping to analyze magnetic resonance imaging scans from 30 depressed patients 59 to 78 years old and 47 nondepressed comparison subjects 55 to 81 years old. RESULTS: Depressed patients had smaller right hippocampal volume than comparison subjects. The volume of the hippocampal-entorhinal cortex was inversely associated with the number of years since the first lifetime episode of depression. CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness.
OBJECTIVE: The authors' goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry. METHOD: They used statistical parametric mapping to analyze magnetic resonance imaging scans from 30 depressedpatients 59 to 78 years old and 47 nondepressed comparison subjects 55 to 81 years old. RESULTS:Depressedpatients had smaller right hippocampal volume than comparison subjects. The volume of the hippocampal-entorhinal cortex was inversely associated with the number of years since the first lifetime episode of depression. CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness.
Authors: Jonathan H Morra; Zhuowen Tu; Liana G Apostolova; Amity E Green; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Xue Hua; Arthur W Toga; Clifford R Jack; Norbert Schuff; Michael W Weiner; Paul M Thompson Journal: Hum Brain Mapp Date: 2009-09 Impact factor: 5.038
Authors: Yi-Yu Chou; Natasha Leporé; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Xue Hua; Leslie M Shaw; John Q Trojanowski; Michael W Weiner; Arthur W Toga; Paul M Thompson Journal: Neuroimage Date: 2009-02-21 Impact factor: 6.556
Authors: Sarah M Szymkowicz; Molly E McLaren; Andrew O'Shea; Adam J Woods; Stephen D Anton; Vonetta M Dotson Journal: Geriatr Gerontol Int Date: 2016-10-02 Impact factor: 2.730
Authors: Martina Ballmaier; Katherine L Narr; Arthur W Toga; Virginia Elderkin-Thompson; Paul M Thompson; Liberty Hamilton; Ebrahim Haroon; Daniel Pham; Andreas Heinz; Anand Kumar Journal: Am J Psychiatry Date: 2007-11-06 Impact factor: 18.112
Authors: P Cédric M P Koolschijn; Neeltje E M van Haren; Gerty J L M Lensvelt-Mulders; Hilleke E Hulshoff Pol; René S Kahn Journal: Hum Brain Mapp Date: 2009-11 Impact factor: 5.038