J L Shea1, M T C King, Y Yi, W Gulliver, G Sun. 1. Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Abstract
BACKGROUND AND AIMS: Nearly 25% of normal weight individuals display abnormal metabolic profiles associated with obesity. As a wide range in body fat percentage (%BF) exists for BMI-defined normal weight individuals, we investigated whether elevated %BF (determined using DXA) was associated with cardiometabolic dysregulation among 977 normal weight subjects (192 men, 785 women) from the Canadian province of Newfoundland and Labrador. METHODS AND RESULTS: BMI and %BF were measured after a 12-h fasting period. Cardiometabolic abnormalities considered included elevated triglyceride, glucose and hsCRP levels, decreased HDL cholesterol, insulin resistance, and hypertension. Subjects were classified as metabolically healthy (0 or 1 cardiometabolic abnormality) or abnormal (≥2 cardiometabolic abnormalities) and divided into sex-specific %BF tertiles as follows: low (≤15.2% men, ≤29.7% women), medium (15.3-20.7%% men, 29.8-34.9%% women) and high (≥20.8% men, ≥35.0% women). The prevalence of the metabolically abnormal phenotype was higher among medium and high %BF subjects (12.0% and 19.5%, respectively) compared to the low group (7.4%; p < 0.05). Furthermore, the odds of being metabolically abnormal were 1.61 (95% CI 0.94-2.77) for medium %BF subjects compared to the low group and nearly tripled for high %BF subjects (OR 2.73, 95% CI 1.63-4.86). ORs remained significant after further adjustment for waist circumference. CONCLUSION: Our findings indicate that those with elevated %BF are at increased risk of developing cardiometabolic disease despite having a normal BMI. Future development of adequate screening tools to identify these individuals is crucial to the prevention of obesity-associated disease.
BACKGROUND AND AIMS: Nearly 25% of normal weight individuals display abnormal metabolic profiles associated with obesity. As a wide range in body fat percentage (%BF) exists for BMI-defined normal weight individuals, we investigated whether elevated %BF (determined using DXA) was associated with cardiometabolic dysregulation among 977 normal weight subjects (192 men, 785 women) from the Canadian province of Newfoundland and Labrador. METHODS AND RESULTS: BMI and %BF were measured after a 12-h fasting period. Cardiometabolic abnormalities considered included elevated triglyceride, glucose and hsCRP levels, decreased HDL cholesterol, insulin resistance, and hypertension. Subjects were classified as metabolically healthy (0 or 1 cardiometabolic abnormality) or abnormal (≥2 cardiometabolic abnormalities) and divided into sex-specific %BF tertiles as follows: low (≤15.2% men, ≤29.7% women), medium (15.3-20.7%% men, 29.8-34.9%% women) and high (≥20.8% men, ≥35.0% women). The prevalence of the metabolically abnormal phenotype was higher among medium and high %BF subjects (12.0% and 19.5%, respectively) compared to the low group (7.4%; p < 0.05). Furthermore, the odds of being metabolically abnormal were 1.61 (95% CI 0.94-2.77) for medium %BF subjects compared to the low group and nearly tripled for high %BF subjects (OR 2.73, 95% CI 1.63-4.86). ORs remained significant after further adjustment for waist circumference. CONCLUSION: Our findings indicate that those with elevated %BF are at increased risk of developing cardiometabolic disease despite having a normal BMI. Future development of adequate screening tools to identify these individuals is crucial to the prevention of obesity-associated disease.
Authors: A De Lorenzo; A Nardi; L Iacopino; E Domino; G Murdolo; C Gavrila; D Minella; G Scapagnini; L Di Renzo Journal: J Endocrinol Invest Date: 2014-01-24 Impact factor: 4.256
Authors: Avery A Thompson; Rachel L Duckham; Mayur M Desai; Courtney C Choy; Lauren B Sherar; Take Naseri; Christina Soti-Ulberg; Muagatutia S Reupena; Abigail I Wetzel; Nicola L Hawley Journal: Pediatr Obes Date: 2020-01-10 Impact factor: 4.000
Authors: Peter M Wolfgram; Ellen L Connor; Jennifer L Rehm; Jens C Eickhoff; Scott B Reeder; David B Allen Journal: Obesity (Silver Spring) Date: 2013-09-17 Impact factor: 5.002
Authors: Jonathan P Singer; Eric R Peterson; Mark E Snyder; Patricia P Katz; Jeffrey A Golden; Frank D'Ovidio; Matthew Bacchetta; Joshua R Sonett; Jasleen Kukreja; Lori Shah; Hilary Robbins; Kristin Van Horn; Rupal J Shah; Joshua M Diamond; Nancy Wickersham; Li Sun; Steven Hays; Selim M Arcasoy; Scott M Palmer; Lorraine B Ware; Jason D Christie; David J Lederer Journal: Am J Respir Crit Care Med Date: 2014-11-01 Impact factor: 21.405
Authors: S R Mirhafez; M Ebrahimi; M Saberi Karimian; A Avan; M Tayefi; A Heidari-Bakavoli; M R Parizadeh; M Moohebati; M R Azarpazhooh; H Esmaily; M Nematy; M Safarian; G A Ferns; M Ghayour-Mobarhan Journal: Eur J Clin Nutr Date: 2016-07-27 Impact factor: 4.016