OBJECTIVE: To report oncological and functional results in women undergoing radical cystectomy and orthotopic bladder replacement. MATERIALS AND METHODS: The charts of all women undergoing bladder replacement after radical cystectomy at UCSF through April 2008 were reviewed. Pathologic characteristics, survival (overall and disease-specific), and urinary functional outcomes are reported. Survival was estimated using Kaplan-Meier methods, and Cox proportional hazards regression analyses were performed to determine factors associated with incontinence, retention, and mortality. RESULTS: Fifty-six women with a mean follow-up of 35 months were analyzed. The cancer recurrence rate was 32%. Kaplan-Meier estimated 5-year recurrence-free, cancer-specific, and overall survival were 54%, 57%, and 47%, respectively. Pathologic lymph node status (HR 14.2, P <.001) and age at diagnosis (HR 1.7, P = .04) were the only clinical or pathologic characteristics significantly associated with survival. The overall continence rate (no pads) was 57%. Hypercontinence occurred in 24% of patients. CONCLUSIONS: With careful patient selection and usage of urethral frozen section, rates of local recurrence are low. Overall rates of incontinence (43%) and hypercontinence (24%) are similar to those previously reported. When pathologically organ-confined, women have an excellent disease-specific survival. Orthotopic bladder replacement is a safe and effective form of urinary diversion after radical cystectomy in women.
OBJECTIVE: To report oncological and functional results in women undergoing radical cystectomy and orthotopic bladder replacement. MATERIALS AND METHODS: The charts of all women undergoing bladder replacement after radical cystectomy at UCSF through April 2008 were reviewed. Pathologic characteristics, survival (overall and disease-specific), and urinary functional outcomes are reported. Survival was estimated using Kaplan-Meier methods, and Cox proportional hazards regression analyses were performed to determine factors associated with incontinence, retention, and mortality. RESULTS: Fifty-six women with a mean follow-up of 35 months were analyzed. The cancer recurrence rate was 32%. Kaplan-Meier estimated 5-year recurrence-free, cancer-specific, and overall survival were 54%, 57%, and 47%, respectively. Pathologic lymph node status (HR 14.2, P <.001) and age at diagnosis (HR 1.7, P = .04) were the only clinical or pathologic characteristics significantly associated with survival. The overall continence rate (no pads) was 57%. Hypercontinence occurred in 24% of patients. CONCLUSIONS: With careful patient selection and usage of urethral frozen section, rates of local recurrence are low. Overall rates of incontinence (43%) and hypercontinence (24%) are similar to those previously reported. When pathologically organ-confined, women have an excellent disease-specific survival. Orthotopic bladder replacement is a safe and effective form of urinary diversion after radical cystectomy in women.
Authors: Urs E Studer; Fiona C Burkhard; Martin Schumacher; Thomas M Kessler; Harriet Thoeny; Achim Fleischmann; George N Thalmann Journal: J Urol Date: 2006-07 Impact factor: 7.450
Authors: Richard E Hautmann; Bjoern G Volkmer; Martin C Schumacher; Juergen E Gschwend; Urs E Studer Journal: World J Urol Date: 2006-07-08 Impact factor: 4.226
Authors: Scott M Gilbert; David P Wood; Rodney L Dunn; Alon Z Weizer; Cheryl T Lee; James E Montie; John T Wei Journal: Cancer Date: 2007-05-01 Impact factor: 6.860