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Literature DB >> 21214222

The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides.

Abstract

The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

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Year: 2011 PMID： 21214222 PMCID： PMC3039074 DOI： 10.1021/ol102915f

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

19 in total

1. Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.

Authors: Hyundae D Cho; Adegboyega K Oyelere; Scott A Strobel; Alan M Weiner
Journal: RNA Date: 2003-08 Impact factor: 4.942

2. Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing.

Authors: Jianmin Gao; Haibo Liu; Eric T Kool
Journal: J Am Chem Soc Date: 2004-09-29 Impact factor: 15.419

3. Dimensional probes of the enzyme binding sites of adenine nucleotides. Biological effects of widening the adenine ring by 2.4 A.

Authors: N J Leonard; D I Scopes; P VanDerLijn; J R Barrio
Journal: Biochemistry Date: 1978-09-05 Impact factor: 3.162

The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides.

1. Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.

2. Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing.

3. Dimensional probes of the enzyme binding sites of adenine nucleotides. Biological effects of widening the adenine ring by 2.4 A.

4. RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase.

5. Matching active site and substrate structures for an RNA editing reaction.

6. Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA.

7. Synthesis and enzymatic incorporation of a fluorescent pyrimidine ribonucleotide.

8. Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine.

9. Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end.

10. Fluorescent probing for RNA molecules by an unnatural base-pair system.

1. Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.

2. Emissive RNA alphabet.

Review 3. Fluorescent nucleobases as tools for studying DNA and RNA.

4. Interbase FRET in RNA: from A to Z.

Review 5. Artificial genetic sets composed of size-expanded base pairs.