Literature DB >> 21212639

rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population.

Ming-Jen Lee1, Ta-Fu Chen, Ting-Wen Cheng, Ming-Jang Chiu.   

Abstract

Progranulin is the precursor of granulins, and its downregulation may lead to neurodegeneration. The single-nucleotide polymorphism rs5848 increases the risk of Alzheimer's disease (AD). We explored the association between alleles of rs5848 and the risk of AD in the Taiwanese population. The frequency of the homozygous TT genotype (16.4 vs. 10.0%) increased in AD subjects by an odds ratio (OR) of 1.87 (p = 0.03) corrected for APOE ε4, age and gender. Interaction between age and homozygous TT genotype accentuated the risk of AD (OR 4.44, p < 0.001). The homozygous TT genotype of rs5848 may play a role in the genetic risk of AD development, especially in the elderly.
Copyright © 2011 S. Karger AG, Basel.

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Year:  2011        PMID： 21212639     DOI： 10.1159/000322538

Source DB:  PubMed          Journal:  Neurodegener Dis        ISSN： 1660-2854            Impact factor:   2.977


  25 in total

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