BACKGROUND: Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. AIM: To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. METHOD: Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main diagnosis or co-diagnosis of bleeding ulcer from 1987 to 2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalisation rates per 100 000 inhabitants in relation to gender, age and ulcer location were calculated as well as age-standardised 30-day mortality rates. RESULTS: Hospitalisations for bleeding ulcer decreased from 63.9 to 35.3 per 100 000 inhabitants per year during the study period. The decrease was greater among men (men: from 80.4 to 40.9; women: from 47.7 to 29.7) and in younger age groups. Bleeding gastric ulcer decreased in both genders, and bleeding duodenal ulcer decreased most among men, but was stable in a subgroup of elderly women. Median age increased from 70 to 76 years. Standardised 30-day mortality increased from 5.3% to 6.2%. The increased mortality was found in those aged more than 65 years and with duodenal ulcer disease, whereas mortality remained unchanged in those with bleeding gastric ulcer. CONCLUSION: Hospitalisation rates for bleeding peptic ulcer have markedly decreased in Sweden in all age groups. The 30-day mortality is low compared with other nationwide studies in the western world, but has increased among patients with duodenal ulcer disease.
BACKGROUND: Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. AIM: To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. METHOD: Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main diagnosis or co-diagnosis of bleeding ulcer from 1987 to 2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalisation rates per 100 000 inhabitants in relation to gender, age and ulcer location were calculated as well as age-standardised 30-day mortality rates. RESULTS: Hospitalisations for bleeding ulcer decreased from 63.9 to 35.3 per 100 000 inhabitants per year during the study period. The decrease was greater among men (men: from 80.4 to 40.9; women: from 47.7 to 29.7) and in younger age groups. Bleeding gastric ulcer decreased in both genders, and bleeding duodenal ulcer decreased most among men, but was stable in a subgroup of elderly women. Median age increased from 70 to 76 years. Standardised 30-day mortality increased from 5.3% to 6.2%. The increased mortality was found in those aged more than 65 years and with duodenal ulcer disease, whereas mortality remained unchanged in those with bleeding gastric ulcer. CONCLUSION: Hospitalisation rates for bleeding peptic ulcer have markedly decreased in Sweden in all age groups. The 30-day mortality is low compared with other nationwide studies in the western world, but has increased among patients with duodenal ulcer disease.
Authors: Nl de Groot; Mgh van Oijen; K Kessels; M Hemmink; Blam Weusten; R Timmer; Wl Hazen; N van Lelyveld; Wl Curvers; Lc Baak; R Verburg; Jh Bosman; Lrh de Wijkerslooth; J de Rooij; Ng Venneman; M Pennings; K van Hee; Rch Scheffer; Rl van Eijk; R Meiland; Pd Siersema; Aj Bredenoord Journal: United European Gastroenterol J Date: 2014-06 Impact factor: 4.623
Authors: Samuel Quan; Alexandra Frolkis; Kaylee Milne; Natalie Molodecky; Hong Yang; Elijah Dixon; Chad G Ball; Robert P Myers; Subrata Ghosh; Robert Hilsden; Sander Veldhuyzen van Zanten; Gilaad G Kaplan Journal: World J Gastroenterol Date: 2014-12-14 Impact factor: 5.742
Authors: Yogesh K Vashist; Emre F Yekebas; Florian Gebauer; Michael Tachezy; Kai Bachmann; Alexandra König; Asad Kutup; Jakob R Izbicki Journal: Langenbecks Arch Surg Date: 2012-08-19 Impact factor: 3.445
Authors: Samuel Quan; Hong Yang; Divine Tanyingoh; Paul J Villeneuve; David M Stieb; Markey Johnson; Robert Hilsden; Karen Madsen; Sander Veldhuyzen van Zanten; Kerri Novak; Eddy Lang; Subrata Ghosh; Gilaad G Kaplan Journal: BMC Gastroenterol Date: 2015-10-14 Impact factor: 3.067