Luigi Mariani1, Salvatore Lo Vullo, Federico Bozzetti. 1. Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy. luigi.mariani@istitutotumori.mi.it
Abstract
PURPOSE: Although weight loss is of both prognostic and predictive relevance in oncologic patients, its assessment is often neglected. Aims of the present investigation were to define the prevalence and severity of weight loss in adult outpatients with a variety of solid tumors, and determine the association patterns with patient-, cancer-, and therapy-related factors. METHODS: Among an outpatient series of 1,556 cancer patients, weight loss information was obtained for 1,540 patients. Weight loss was analyzed by means of multiple regression models, logistic models, and nomograms, according to age, gender, site of primary, UICC stage, Eastern Cooperative Oncology Group (ECOG) performance status, therapy, and symptoms type and degree. RESULTS: Weight loss, relative to usual body weight, was 7.1% on average in the whole series, and clinically significant (≥ 10%) in 589 patients (38%). Factors most strongly associated with WL were site of primary, ECOG performance status, anorexia syndrome, and fatigue. These, together with oncologic therapy, were important factors for predicting significant weight loss. CONCLUSIONS: Weight loss turned out to be frequent and clinically significant. We believe that this sign should deserve major attention by the oncologists to pursue the benefits that early nutritional support prospectively yields in terms of quality of life and clinical outcome improvement.
PURPOSE: Although weight loss is of both prognostic and predictive relevance in oncologic patients, its assessment is often neglected. Aims of the present investigation were to define the prevalence and severity of weight loss in adult outpatients with a variety of solid tumors, and determine the association patterns with patient-, cancer-, and therapy-related factors. METHODS: Among an outpatient series of 1,556 cancerpatients, weight loss information was obtained for 1,540 patients. Weight loss was analyzed by means of multiple regression models, logistic models, and nomograms, according to age, gender, site of primary, UICC stage, Eastern Cooperative Oncology Group (ECOG) performance status, therapy, and symptoms type and degree. RESULTS:Weight loss, relative to usual body weight, was 7.1% on average in the whole series, and clinically significant (≥ 10%) in 589 patients (38%). Factors most strongly associated with WL were site of primary, ECOG performance status, anorexia syndrome, and fatigue. These, together with oncologic therapy, were important factors for predicting significant weight loss. CONCLUSIONS:Weight loss turned out to be frequent and clinically significant. We believe that this sign should deserve major attention by the oncologists to pursue the benefits that early nutritional support prospectively yields in terms of quality of life and clinical outcome improvement.
Authors: Eric Van Cutsem; Vladimir M Moiseyenko; Sergei Tjulandin; Alejandro Majlis; Manuel Constenla; Corrado Boni; Adriano Rodrigues; Miguel Fodor; Yee Chao; Edouard Voznyi; Marie-Laure Risse; Jaffer A Ajani Journal: J Clin Oncol Date: 2006-11-01 Impact factor: 44.544
Authors: Jeannine Bachmann; Mathias Heiligensetzer; Holger Krakowski-Roosen; Markus W Büchler; Helmut Friess; Marc E Martignoni Journal: J Gastrointest Surg Date: 2008-03-18 Impact factor: 3.452
Authors: Nilanjana Tewari; Antonio E Martin-Ucar; Edward Black; Lynda Beggs; F David Beggs; John P Duffy; W Ellis Morgan Journal: Lung Cancer Date: 2007-05-03 Impact factor: 5.705
Authors: W D Dewys; C Begg; P T Lavin; P R Band; J M Bennett; J R Bertino; M H Cohen; H O Douglass; P F Engstrom; E Z Ezdinli; J Horton; G J Johnson; C G Moertel; M M Oken; C Perlia; C Rosenbaum; M N Silverstein; R T Skeel; R W Sponzo; D C Tormey Journal: Am J Med Date: 1980-10 Impact factor: 4.965
Authors: Bhavani S Gannavarapu; Steven K M Lau; Kristen Carter; Nathan A Cannon; Ang Gao; Chul Ahn; Jeffrey J Meyer; David J Sher; Aminah Jatoi; Rodney Infante; Puneeth Iyengar Journal: J Oncol Pract Date: 2018-02-21 Impact factor: 3.840
Authors: Federico Bozzetti; Luigi Mariani; Salvatore Lo Vullo; Maria Luisa Amerio; Roberto Biffi; Giovanni Caccialanza; Giorgio Capuano; Giovanni Capuano; Isabel Correja; Luca Cozzaglio; Angelo Di Leo; Leonardo Di Cosmo; Concetta Finocchiaro; Cecilia Gavazzi; Antonello Giannoni; Patrizia Magnanini; Giovanni Mantovani; Manuela Pellegrini; Lidia Rovera; Giancarlo Sandri; Marco Tinivella; Enrico Vigevani Journal: Support Care Cancer Date: 2012-08 Impact factor: 3.603
Authors: Paolo Cotogni; Luca De Carli; Roberto Passera; Maria Luisa Amerio; Elena Agnello; Maurizio Fadda; Marta Ossola; Taira Monge; Antonella De Francesco; Federico Bozzetti Journal: Cancer Med Date: 2017-05-29 Impact factor: 4.452
Authors: Mónica Patricia Cala; María Teresa Agulló-Ortuño; Elena Prieto-García; Carolina González-Riano; Lucía Parrilla-Rubio; Coral Barbas; Carmen Vanesa Díaz-García; Antonia García; Cristina Pernaut; Jorge Adeva; María Carmen Riesco; Francisco Javier Rupérez; Jose Antonio Lopez-Martin Journal: J Cachexia Sarcopenia Muscle Date: 2018-02-20 Impact factor: 12.910