Literature DB >> 21208926

West nile virus RNA not detected in urine of 40 people tested 6 years after acute West Nile virus disease.

Katherine B Gibney1, Robert S Lanciotti, James J Sejvar, C Thomas Nugent, Jeffrey M Linnen, Mark J Delorey, Jennifer A Lehman, Erin N Boswell, J Erin Staples, Marc Fischer.   

Abstract

West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.

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Year:  2010        PMID: 21208926      PMCID: PMC3071119          DOI: 10.1093/infdis/jiq057

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  15 in total

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4.  Persistent shedding of West Nile virus in urine of experimentally infected hamsters.

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Journal:  Am J Trop Med Hyg       Date:  2005-03       Impact factor: 2.345

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Authors:  Jessica H Tonry; Craig B Brown; Cecil B Cropp; Juliene K G Co; Shannon N Bennett; Vivek R Nerurkar; Timothy Kuberski; Duane J Gubler
Journal:  Emerg Infect Dis       Date:  2005-08       Impact factor: 6.883

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  22 in total

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Review 5.  Persistent RNA virus infections: do PAMPS drive chronic disease?

Authors:  Mary K McCarthy; Thomas E Morrison
Journal:  Curr Opin Virol       Date:  2017-02-17       Impact factor: 7.090

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7.  Of Mice and Men: Protective and Pathogenic Immune Responses to West Nile virus Infection.

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Review 8.  Age-related changes in CD8 T cell homeostasis and immunity to infection.

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Review 10.  West Nile virus: review of the literature.

Authors:  Lyle R Petersen; Aaron C Brault; Roger S Nasci
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