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Literature DB >> 21208901

Molecular targeting of neural cancer stem cells: TTAGGG, you're it!

Abstract

Telomerase is an important mechanism by which cancers escape replicative senescence. In neural tumors, cancer stem cells express telomerase, suggesting that this may explain their preferential tumorigenesis. Oligonucleotide telomerase targeting selectively disrupts cancer stem cell growth through the induction of differentiation, adding to the armamentarium of anticancer stem cell therapies. ©2011 AACR.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Telomerase

Year: 2011 PMID： 21208901 PMCID： PMC3099413 DOI： 10.1158/1078-0432.CCR-10-2686

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

12 in total

1. Telomerase activity and alterations in telomere length in human brain tumors.

Authors: S Hiraga; T Ohnishi; S Izumoto; E Miyahara; Y Kanemura; H Matsumura; N Arita
Journal: Cancer Res Date: 1998-05-15 Impact factor: 12.701

2. Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition.

Authors: Pedro Castelo-Branco; Cindy Zhang; Tatiana Lipman; Mayumi Fujitani; Loen Hansford; Ian Clarke; Calvin B Harley; Robert Tressler; David Malkin; Erin Walker; David R Kaplan; Peter Dirks; Uri Tabori
Journal: Clin Cancer Res Date: 2011-01-01 Impact factor: 12.531

3. Creation of human tumour cells with defined genetic elements.

Authors: W C Hahn; C M Counter; A S Lundberg; R L Beijersbergen; M W Brooks; R A Weinberg
Journal: Nature Date: 1999-07-29 Impact factor: 49.962

Review 4. Telomerase as a therapeutic target for malignant gliomas.

Authors: Tadashi Komata; Takao Kanzawa; Yasuko Kondo; Seiji Kondo
Journal: Oncogene Date: 2002-01-21 Impact factor: 9.867

Review 5. Telomeres and telomerase in normal and cancer stem cells.

Authors: Jerry W Shay; Woodring E Wright
Journal: FEBS Lett Date: 2010-05-21 Impact factor: 4.124

6. Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme.

Authors: V Hakin-Smith; D A Jellinek; D Levy; T Carroll; M Teo; W R Timperley; M J McKay; R R Reddel; J A Royds
Journal: Lancet Date: 2003-03-08 Impact factor: 79.321

7. Telomerase activity in human brain tumours.

Authors: L A Langford; M A Piatyszek; R Xu; S C Schold; J W Shay
Journal: Lancet Date: 1995-11-11 Impact factor: 79.321

8. Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts.

Authors: Tomoko Ozawa; Sergei M Gryaznov; Lily J Hu; Krisztina Pongracz; Raquel A Santos; Andrew W Bollen; Kathleen R Lamborn; Dennis F Deen
Journal: Neuro Oncol Date: 2004-07 Impact factor: 12.300

9. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.

Authors: Calin O Marian; Steve K Cho; Brian M McEllin; Elizabeth A Maher; Kimmo J Hatanpaa; Christopher J Madden; Bruce E Mickey; Woodring E Wright; Jerry W Shay; Robert M Bachoo
Journal: Clin Cancer Res Date: 2010-01-01 Impact factor: 12.531