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Literature DB >> 21203934

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites.

Hong Gao¹, Ying Zhuo, Elizabeth Ashforth, Lixin Zhang.

Abstract

Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology. However, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites.

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Year: 2010 PMID： 21203934 PMCID： PMC4875272 DOI： 10.1007/s13238-010-0073-3

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

36 in total

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9. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria.

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