OBJECTIVES: It was evaluated epidemiological aspects of primary lip squamous cell carcinoma (LSCC) and its associations with clinicopathological factors. STUDY DESIGN: This retrospective, cross-sectional study analysed a socio-demographic, clinical, and morphological data of HNSCC in a Brazilian population (n=30). Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher 's exact tests to compare the variables. RESULTS: The LSCC represented 10.8% of all oral cavity squamous cell carcinoma. Lip malignant disease was more prevalent in elderly men, with male-to-female ratio of 5:1. Lower lip was more affected. It was observed high rates of chronic solar exposure, and tobacco and alcohol drinking habits. Clinically, early TNM staging, small tumour lesions, and non-metastatic disease were predominant findings. It was identified a high frequency of well differentiated tumor samples. Worse Karnofsky performance status was associated with cervical metastasis. CONCLUSIONS: Our findings showed that LSCC patients exhibited similar epidemiological and clinical profiles as noted in other studies. Still, the occurrence of metastatic disease was associated with a worse physical performance status of the LSCC patients during diagnosis.
OBJECTIVES: It was evaluated epidemiological aspects of primary lip squamous cell carcinoma (LSCC) and its associations with clinicopathological factors. STUDY DESIGN: This retrospective, cross-sectional study analysed a socio-demographic, clinical, and morphological data of HNSCC in a Brazilian population (n=30). Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher 's exact tests to compare the variables. RESULTS: The LSCC represented 10.8% of all oral cavity squamous cell carcinoma. Lip malignant disease was more prevalent in elderly men, with male-to-female ratio of 5:1. Lower lip was more affected. It was observed high rates of chronic solar exposure, and tobacco and alcohol drinking habits. Clinically, early TNM staging, small tumour lesions, and non-metastatic disease were predominant findings. It was identified a high frequency of well differentiated tumor samples. Worse Karnofsky performance status was associated with cervical metastasis. CONCLUSIONS: Our findings showed that LSCC patients exhibited similar epidemiological and clinical profiles as noted in other studies. Still, the occurrence of metastatic disease was associated with a worse physical performance status of the LSCC patients during diagnosis.
Authors: Leni Verônica de Oliveira Silva; José Alcides Almeida de Arruda; Lucas Guimarães Abreu; Raquel Conceição Ferreira; Leorik Pereira da Silva; Cibele Pelissari; Ricardo Natã Fonseca Silva; Kaio Heide Sampaio Nóbrega; Bruno Augusto Benevenuto de Andrade; Mario José Romañach; Michelle Agostini; Cassiano Francisco Weege Nonaka; Pollianna Muniz Alves; Hélder Antônio Rebelo Pontes; Luís Fernando Rivero; Lélia Batista de Souza; Marília Trierveiler; Elismauro Francisco Mendonça; Ana Paula Neutzling Gomes; Manoela Domingues Martins; Emanuel Sávio de Souza Andrade; Marcia Maria Fonseca da Silveira; Ana Paula Veras Sobral; Ricardo Alves Mesquita Journal: Head Neck Pathol Date: 2020-02-19
Authors: Breno A Rocha; Lucianne M C Lima; Lívia M R Paranaíba; Angel da S Martinez; Maria Betânia de O Pires; Edimilson M de Freitas; Camilla V Vilas Boas; Mário R de Melo Filho Journal: Rep Pract Oncol Radiother Date: 2017-09-01