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Literature DB >> 21196345

CD133 negative cancer stem cells in glioblastoma.

Abstract

Glioblastomas (GBM) are paradigmatic for the investigation of cancer stem cells (CSC) in solid tumors. Recently, the discovery of CD133- CSC in addition to CD133+ CSC has substantially added to our understanding of the complexity of GBM CSC. This review gives an overview on our current knowledge on CD133- cells in GBM and describes five different hypothesizes on the nature of CD133- cells in GBM. In addition, we summarize the current knowledge on tumorigenic CD133- CSC, list available markers, describe the current controversies on the origin of CD133- CSC, and discuss how the heterogeneity of CSC may correspond to the molecular heterogeneity of GBM.

Entities: Chemical

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Year: 2011 PMID： 21196345 DOI： 10.2741/e280

Source DB: PubMed Journal: Front Biosci (Elite Ed) ISSN： 1945-0494

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Cited

15 in total

Review 1. Emerging insights into the molecular and cellular basis of glioblastoma.

Authors: Gavin P Dunn; Mikael L Rinne; Jill Wykosky; Giannicola Genovese; Steven N Quayle; Ian F Dunn; Pankaj K Agarwalla; Milan G Chheda; Benito Campos; Alan Wang; Cameron Brennan; Keith L Ligon; Frank Furnari; Webster K Cavenee; Ronald A Depinho; Lynda Chin; William C Hahn
Journal: Genes Dev Date: 2012-04-15 Impact factor: 11.361

2. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity.

Authors: Xiuli Jiang; Hongyan Xing; Tae-Min Kim; Yuchae Jung; Wei Huang; Hong Wei Yang; Shengye Song; Peter J Park; Rona S Carroll; Mark D Johnson
Journal: Stem Cells Date: 2012-07 Impact factor: 6.277

Review 3. Lessons from common markers of tumor-initiating cells in solid cancers.

Authors: Olivier Gires
Journal: Cell Mol Life Sci Date: 2011-07-24 Impact factor: 9.261

Review 4. Brain mesenchymal stem cells: The other stem cells of the brain?

Authors: Florence Appaix; Marie-France Nissou; Boudewijn van der Sanden; Matthieu Dreyfus; François Berger; Jean-Paul Issartel; Didier Wion
Journal: World J Stem Cells Date: 2014-04-26 Impact factor: 5.326

5. Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.

Authors: Tooba A Cheema; Hiroaki Wakimoto; Peter E Fecci; Jianfang Ning; Toshihiko Kuroda; Deva S Jeyaretna; Robert L Martuza; Samuel D Rabkin
Journal: Proc Natl Acad Sci U S A Date: 2013-06-10 Impact factor: 11.205

6. Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.

Authors: Jun Wang; Jared Bushman; Xi Wang; Margot Mayer-Proschel; Mahlon Johnson; Mark Noble
Journal: J Neurosci Date: 2013-10-16 Impact factor: 6.167

10. CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile.

Authors: Zangiacomi Vincent; Kenichi Urakami; Koji Maruyama; Ken Yamaguchi; Masatoshi Kusuhara
Journal: Genes Cancer Date: 2014-07