BACKGROUND: Nocturnal oxyhaemoglobin desaturation is common in cystic fibrosis (CF) but the effect on quality of life (QoL) remains unknown. METHODS: Sixty stable CF outpatients with mean age 31±8 years (mean±1 SD), BMI 20.8±3.2 kg/m(2) and FEV(1) 42±13% predicted had arterial blood gas sampling, lung function testing, overnight pulse oximetry and completed the CF QoL questionnaire, Epworth Sleepiness Scale and Medical Research Council dyspnoea scale. RESULTS: 11 (18%) of the CF patients were 'desaturators,' (SpO(2)<90% for ≥30% recording time on overnight oximetry). Desaturators had greater difficulty performing their treatments (39±22 vs 61±26, p<0.01) and more exertional dyspnoea (3.2±0.8 vs 2.0±0.9, p<0.001) than non-desaturators after controlling for the effects of FEV(1), awake PaO(2) and PaCO(2) (adjusted p-values <0.01 and 0.04 respectively). CONCLUSIONS: Nocturnal oxyhaemoglobin desaturation is associated with impaired QoL, independent of the effects of lung function and awake gas exchange, in stable CF outpatients with moderate to severe lung disease.
BACKGROUND: Nocturnal oxyhaemoglobin desaturation is common in cystic fibrosis (CF) but the effect on quality of life (QoL) remains unknown. METHODS: Sixty stable CF outpatients with mean age 31±8 years (mean±1 SD), BMI 20.8±3.2 kg/m(2) and FEV(1) 42±13% predicted had arterial blood gas sampling, lung function testing, overnight pulse oximetry and completed the CF QoL questionnaire, Epworth Sleepiness Scale and Medical Research Council dyspnoea scale. RESULTS: 11 (18%) of the CF patients were 'desaturators,' (SpO(2)<90% for ≥30% recording time on overnight oximetry). Desaturators had greater difficulty performing their treatments (39±22 vs 61±26, p<0.01) and more exertional dyspnoea (3.2±0.8 vs 2.0±0.9, p<0.001) than non-desaturators after controlling for the effects of FEV(1), awake PaO(2) and PaCO(2) (adjusted p-values <0.01 and 0.04 respectively). CONCLUSIONS: Nocturnal oxyhaemoglobin desaturation is associated with impaired QoL, independent of the effects of lung function and awake gas exchange, in stable CF outpatients with moderate to severe lung disease.
Authors: Rodrigo Dos Santos Lugao; Roberta Ribeiro Batista Barbosa; Pitiguara de Freitas Coelho; Fernanda Mayrink Gonçalves Liberato; Pâmela Reis Vidal; Roberta Barcellos Couto Olimpio de Carvalho; Roberta de Cássia Nunes Cruz Melotti; Márcio Vinícius Fagundes Donadio Journal: Rev Paul Pediatr Date: 2021-09-01