Literature DB >> 21191390

TWEAK-Fn14 as a mediator of acute kidney injury.

Joel M Weinberg1.   

Abstract

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 (TWEAK-Fn14), are widely expressed and are involved in both injury and repair. Hotta et al. now demonstrate an important role for Fn14 in the common clamp ischemia model of acute kidney injury. Their data suggest paracrine and autocrine effects in which TWEAK produced by tubule cells feeds back on them via upregulated Fn-14 receptors expressed downstream in the proximal tubule.

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Year:  2011        PMID： 21191390      PMCID： PMC3125134          DOI： 10.1038/ki.2010.435

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  15 in total

1.  Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury.

Authors:  Kiyohiko Hotta; Masayuki Sho; Ichiro Yamato; Keiji Shimada; Hiroshi Harada; Takahiro Akahori; Shinji Nakamura; Noboru Konishi; Hideo Yagita; Katsuya Nonomura; Yoshiyuki Nakajima
Journal:  Kidney Int       Date:  2010-10-06       Impact factor: 10.612

2.  Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway.

Authors:  Sharron A N Brown; Arundhati Ghosh; Jeffrey A Winkles
Journal:  J Biol Chem       Date:  2010-04-12       Impact factor: 5.157

3.  TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.

Authors:  Y Chicheportiche; P R Bourdon; H Xu; Y M Hsu; H Scott; C Hession; I Garcia; J L Browning
Journal:  J Biol Chem       Date:  1997-12-19       Impact factor: 5.157

4.  Cytokine cooperation in renal tubular cell injury: the role of TWEAK.

Authors:  P Justo; A B Sanz; M D Sanchez-Niño; J A Winkles; C Lorz; J Egido; A Ortiz
Journal:  Kidney Int       Date:  2006-09-27       Impact factor: 10.612

Review 5.  TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease.

Authors:  Linda C Burkly; Jennifer S Michaelson; Kyungmin Hahm; Aniela Jakubowski; Timothy S Zheng
Journal:  Cytokine       Date:  2007-11-05       Impact factor: 3.861

6.  The cytokine TWEAK modulates renal tubulointerstitial inflammation.

Authors:  Ana Belen Sanz; Pilar Justo; Maria Dolores Sanchez-Niño; Luis Miguel Blanco-Colio; Jeffrey A Winkles; Matthias Kreztler; Aniela Jakubowski; Julia Blanco; Jesús Egido; Marta Ruiz-Ortega; Alberto Ortiz
Journal:  J Am Soc Nephrol       Date:  2008-01-30       Impact factor: 10.121

Review 7.  The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting.

Authors:  Jeffrey A Winkles
Journal:  Nat Rev Drug Discov       Date:  2008-05       Impact factor: 84.694

8.  Additive effects of soluble TWEAK and inflammation on mortality in hemodialysis patients.

Authors:  Juan J Carrero; Alberto Ortiz; Abdul R Qureshi; Jose L Martín-Ventura; Peter Bárány; Olof Heimbürger; Belén Marrón; George Metry; Sunna Snaedal; Bengt Lindholm; Jesús Egido; Peter Stenvinkel; Luis M Blanco-Colio
Journal:  Clin J Am Soc Nephrol       Date:  2008-10-22       Impact factor: 8.237

9.  TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity.

Authors:  Binzhi Zhang; Ganesan Ramesh; Satoshi Uematsu; Shizuo Akira; W Brian Reeves
Journal:  J Am Soc Nephrol       Date:  2008-02-06       Impact factor: 10.121

10.  Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia.

Authors:  Ana B Sanz; Maria Dolores Sanchez-Niño; Maria Concepcion Izquierdo; Aniela Jakubowski; Pilar Justo; Luis M Blanco-Colio; Marta Ruiz-Ortega; Jesús Egido; Alberto Ortiz
Journal:  J Cell Mol Med       Date:  2009-05-01       Impact factor: 5.310
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  8 in total

1.  Biomeasures and mechanistic modeling highlight PK/PD risks for a monoclonal antibody targeting Fn14 in kidney disease.

Authors:  Xiaoying Chen; Vahid Farrokhi; Pratap Singh; Mireia Fernandez Ocana; Jenil Patel; Lih-Ling Lin; Hendrik Neubert; Joanne Brodfuehrer
Journal:  MAbs       Date:  2017-11-30       Impact factor: 5.857

2.  Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis.

Authors:  Zhijie Li; Heming Wang; Junjin Zhu; Ning Nan; Yi Lin; Xuran Zhuang; Ling Li; Yamin Zhang; Pengyu Huang
Journal:  Cell Death Discov       Date:  2022-07-19

3.  A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway.

Authors:  Mitali Bhattacharjee; Rajesh Raju; Aneesha Radhakrishnan; Vishalakshi Nanjappa; Babylakshmi Muthusamy; Kamlendra Singh; Dheebika Kuppusamy; Bhavya Teja Lingala; Archana Pan; Premendu Prakash Mathur; H C Harsha; T S Keshava Prasad; Gerald J Atkins; Akhilesh Pandey; Aditi Chatterjee
Journal:  J Signal Transduct       Date:  2012-05-09

4.  Soluble Fn14 Is Detected and Elevated in Mouse and Human Kidney Disease.

Authors:  M Nusrat Sharif; Gabriela Campanholle; Eva E Nagiec; Ju Wang; Jameel Syed; Shawn P O'Neil; Yutian Zhan; Karrie Brenneman; Bruce Homer; Hendrik Neubert; Riyez Karim; Nick Pullen; Steven M Evans; Margaret Fleming; Priya Chockalingam; Lih-Ling Lin
Journal:  PLoS One       Date:  2016-05-12       Impact factor: 3.240

Review 5.  TWEAK/Fn14 Activation Participates in Skin Inflammation.

Authors:  Qilu Liu; Shengxiang Xiao; Yumin Xia
Journal:  Mediators Inflamm       Date:  2017-09-06       Impact factor: 4.711

6.  Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries.

Authors:  Ming Lyu; Ying Cui; Tiechan Zhao; Zhaochen Ning; Jie Ren; Xingpiao Jin; Guanwei Fan; Yan Zhu
Journal:  Front Pharmacol       Date:  2018-04-06       Impact factor: 5.810

7.  Polystyrene Nanoplastics Induce Lung Injury via Activating Oxidative Stress: Molecular Insights from Bioinformatics Analysis.

Authors:  Tianyi Zhang; Sheng Yang; Yiling Ge; Xin Wan; Yuxin Zhu; Jie Li; Lihong Yin; Yuepu Pu; Geyu Liang
Journal:  Nanomaterials (Basel)       Date:  2022-10-07       Impact factor: 5.719

8.  PGC1α plays a critical role in TWEAK-induced cardiac dysfunction.

Authors:  Jianru Shi; Bingbing Jiang; Yiling Qiu; Jian Guan; Mohit Jain; Xin Cao; Michael Bauer; Lihe Su; Linda C Burkly; Teresa C Leone; Daniel P Kelly; Ronglih Liao
Journal:  PLoS One       Date:  2013-01-16       Impact factor: 3.240
  8 in total

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