Literature DB >> 18404150

The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting.

Jeffrey A Winkles1.   

Abstract

TWEAK is a multifunctional cytokine that controls many cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK acts by binding to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-kappaB (NF-kappaB) pathway. The TWEAK-Fn14 axis normally regulates various physiological processes, in particular it seems to play an important, beneficial role in tissue repair following acute injury. Furthermore, recent studies have indicated that TWEAK-Fn14 axis signalling may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke. This Review provides an overview of TWEAK-Fn14 axis biology and summarizes the available data supporting the proposal that both TWEAK and Fn14 should be considered as potential targets for the development of novel therapeutics.

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Year:  2008        PMID： 18404150      PMCID： PMC3018765          DOI： 10.1038/nrd2488

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  132 in total

Review 1.  The TNF and TNF receptor superfamilies: integrating mammalian biology.

Authors:  R M Locksley; N Killeen; M J Lenardo
Journal:  Cell       Date:  2001-02-23       Impact factor: 41.582

2.  Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).

Authors:  A Kaptein; M Jansen; G Dilaver; J Kitson; L Dash; E Wang; M J Owen; J L Bodmer; J Tschopp; S N Farrow
Journal:  FEBS Lett       Date:  2000-11-24       Impact factor: 4.124

3.  Death receptor-3 mediates apoptosis in human osteoblasts under narrowly regulated conditions.

Authors:  Christopher W Borysenko; Verónica García-Palacios; Reed D Griswold; Yanan Li; Anand Krishnan V Iyer; Beatrice B Yaroslavskiy; Allison C Sharrow; Harry C Blair
Journal:  J Cell Physiol       Date:  2006-12       Impact factor: 6.384

4.  Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.

Authors:  Nhan L Tran; Wendy S McDonough; Benjamin A Savitch; Shannon P Fortin; Jeffrey A Winkles; Marc Symons; Mitsutoshi Nakada; Heather E Cunliffe; Galen Hostetter; Dominique B Hoelzinger; Jessica L Rennert; Jennifer S Michaelson; Linda C Burkly; Christopher A Lipinski; Joseph C Loftus; Luigi Mariani; Michael E Berens
Journal:  Cancer Res       Date:  2006-10-01       Impact factor: 12.701

Review 5.  Inflammation in stroke and focal cerebral ischemia.

Authors:  Judy Huang; Urvashi M Upadhyay; Rafael J Tamargo
Journal:  Surg Neurol       Date:  2006-09

6.  A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.

Authors:  S R Wiley; L Cassiano; T Lofton; T Davis-Smith; J A Winkles; V Lindner; H Liu; T O Daniel; C A Smith; W C Fanslow
Journal:  Immunity       Date:  2001-11       Impact factor: 31.745

7.  Intraovarian tumor necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible-14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization.

Authors:  Ananya De; Jae-Il Park; Kazuhiro Kawamura; Ruby Chen; Cynthia Klein; Rami Rauch; Sabine M Mulders; Maarten D Sollewijn Gelpke; Aaron J W Hsueh
Journal:  Mol Endocrinol       Date:  2006-06-08

8.  Down-regulated expression of TWEAK mRNA in acute and chronic inflammatory pathologies.

Authors:  Y Chicheportiche; L Fossati-Jimack; S Moll; N Ibnou-Zekri; S Izui
Journal:  Biochem Biophys Res Commun       Date:  2000-12-09       Impact factor: 3.575

9.  Multiple pathways of TWEAK-induced cell death.

Authors:  Masafumi Nakayama; Kazumi Ishidoh; Nobuhiko Kayagaki; Yuko Kojima; Noriko Yamaguchi; Hiroyasu Nakano; Eiki Kominami; Ko Okumura; Hideo Yagita
Journal:  J Immunol       Date:  2002-01-15       Impact factor: 5.422

10.  Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity.

Authors:  M Nakayama; N Kayagaki; N Yamaguchi; K Okumura; H Yagita
Journal:  J Exp Med       Date:  2000-11-06       Impact factor: 14.307
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  226 in total

1.  IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective.

Authors:  J Silke; J E Vince
Journal:  Cell Death Differ       Date:  2012-01       Impact factor: 15.828

2.  Impact of antihypertensive drugs on TNF-like weak inducer of apoptosis.

Authors:  Xiaoqi Shen
Journal:  Clin Rheumatol       Date:  2012-03-13       Impact factor: 2.980

3.  Genetic ablation of TWEAK augments regeneration and post-injury growth of skeletal muscle in mice.

Authors:  Ashwani Mittal; Shephali Bhatnagar; Akhilesh Kumar; Pradyut K Paul; Shihuan Kuang; Ashok Kumar
Journal:  Am J Pathol       Date:  2010-08-19       Impact factor: 4.307

Review 4.  Role of TWEAK in lupus nephritis: a bench-to-bedside review.

Authors:  Jennifer S Michaelson; Nicolas Wisniacki; Linda C Burkly; Chaim Putterman
Journal:  J Autoimmun       Date:  2012-06-22       Impact factor: 7.094

5.  Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program.

Authors:  Sajedah M Hindi; Vivek Mishra; Shephali Bhatnagar; Marjan M Tajrishi; Yuji Ogura; Zhen Yan; Linda C Burkly; Timothy S Zheng; Ashok Kumar
Journal:  FASEB J       Date:  2013-12-10       Impact factor: 5.191

6.  EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival.

Authors:  Alison Roos; Harshil D Dhruv; Sen Peng; Landon J Inge; Serdar Tuncali; Michael Pineda; Nghia Millard; Zachary Mayo; Jennifer M Eschbacher; Joseph C Loftus; Jeffrey A Winkles; Nhan L Tran
Journal:  Mol Cancer Res       Date:  2018-05-03       Impact factor: 5.852

7.  Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy.

Authors:  Hong Li; Ashwani Mittal; Pradyut K Paul; Mukesh Kumar; Daya S Srivastava; Suresh C Tyagi; Ashok Kumar
Journal:  J Biol Chem       Date:  2008-12-11       Impact factor: 5.157

8.  Soluble Tumor Necrosis Factor Like Weak Inducer of Apoptosis and Vitamin D in Hemodialysis Patients: Relation to Carotid Intima-Media Thickness.

Authors:  Farahnaz Askarian; Amir Ghorbanihaghjo; Hassan Argani; Davoud Sanajou; Nima Nasehi; Roya Askarian; Ravan Ahmadi; Nadereh Rahtchizadeh
Journal:  Indian J Clin Biochem       Date:  2017-07-22

9.  Soluble TWEAK levels are independently associated with coronary artery disease severity in patients with stage 2-3 kidney disease.

Authors:  Alper Azak; Mehmet Fatih Akdoğan; Nazım Denizli; Bülent Huddam; Gülay Koçak; Murat Gücün; Mustafa Adem Tatlısu; Recep Demirci; Bilal Yılmaz; Mehmet Dikeç; Murat Bakırtaş; Ibrahim Akdağ; Murat Duranay
Journal:  Int Urol Nephrol       Date:  2013-09-17       Impact factor: 2.370

10.  Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults.

Authors:  Maryam Keshtkar-Jahromi; Min Ouyang; Marzieh Keshtkarjahromi; Samah Almed; Huifen Li; Jeremy D Walston; Rebeca Rios; Sean X Leng
Journal:  Vaccine       Date:  2018-03-13       Impact factor: 3.641
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