BACKGROUND: Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters. MATERIALS AND METHODS: A subset of 46 samples from patients with enteropancreatic NETs (26 male and 20 female) were selected for evaluation. The tissue slides were stained with a mouse monoclonal antiphospho-Akt antibody using the avidin-biotin-complex method. RESULTS: The tumors were from the small (n = 18) and large bowel (n = 9) and from the pancreas (n = 16). Activation of Akt was detected in 61% (28/46) of cases. No statistical correlation was found between the p-Akt score and tumor grade (p = 0.72), tumor size (p = 0.72) and the presence of metastases (p = 0.52). CONCLUSION: This study shows activation of Akt in a subset of enteropancreatic NET for the first time. This finding suggests a role of p-Akt in NET carcinogenesis.
BACKGROUND:Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters. MATERIALS AND METHODS: A subset of 46 samples from patients with enteropancreatic NETs (26 male and 20 female) were selected for evaluation. The tissue slides were stained with a mouse monoclonal antiphospho-Akt antibody using the avidin-biotin-complex method. RESULTS: The tumors were from the small (n = 18) and large bowel (n = 9) and from the pancreas (n = 16). Activation of Akt was detected in 61% (28/46) of cases. No statistical correlation was found between the p-Akt score and tumor grade (p = 0.72), tumor size (p = 0.72) and the presence of metastases (p = 0.52). CONCLUSION: This study shows activation of Akt in a subset of enteropancreatic NET for the first time. This finding suggests a role of p-Akt in NET carcinogenesis.
Authors: Rony A François; Kyungah Maeng; Akbar Nawab; Frederic J Kaye; Steven N Hochwald; Maria Zajac-Kaye Journal: J Natl Cancer Inst Date: 2015-05-12 Impact factor: 13.506
Authors: Chandra K Maharjan; Po Hien Ear; Catherine G Tran; James R Howe; Chandrikha Chandrasekharan; Dawn E Quelle Journal: Cancers (Basel) Date: 2021-10-12 Impact factor: 6.639
Authors: Rossana Berardi; Mariangela Torniai; Sara Pusceddu; Francesca Spada; Toni Ibrahim; Maria Pia Brizzi; Lorenzo Antonuzzo; Piero Ferolla; Francesco Panzuto; Nicola Silvestris; Stefano Partelli; Benedetta Ferretti; Federica Freddari; Calogero Gucciardino; Enrica Testa; Laura Concas; Sabina Murgioni; Alberto Bongiovanni; Clizia Zichi; Nada Riva; Maria Rinzivillo; Oronzo Brunetti; Lucio Giustini; Francesco Di Costanzo; Gianfranco Delle Fave; Nicola Fazio; Filippo De Braud; Massimo Falconi; Stefano Cascinu Journal: Cancer Med Date: 2017-05-25 Impact factor: 4.452