Literature DB >> 21186281

Hijacking solute carriers for proton-coupled drug transport.

Catriona M H Anderson1, David T Thwaites.   

Abstract

The physiological role of mammalian solute carrier (SLC) proteins is to mediate transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and endogenous metabolites from one cellular compartment to another. Many transporters in the small intestine, kidney, and solid tumors are H(+)-coupled, driven by local H(+)-electrochemical gradients, and transport numerous drugs. These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).

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Year:  2010        PMID： 21186281     DOI： 10.1152/physiol.00027.2010

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  27 in total

Review 1.  Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.

Authors:  Jaleh Barar; Yadollah Omidi
Journal:  Bioimpacts       Date:  2013-12-10

Review 2.  The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.

Authors:  David T Thwaites; Catriona M H Anderson
Journal:  Br J Pharmacol       Date:  2011-12       Impact factor: 8.739

Review 3.  The organic anion transporter (OAT) family: a systems biology perspective.

Authors:  Sanjay K Nigam; Kevin T Bush; Gleb Martovetsky; Sun-Young Ahn; Henry C Liu; Erin Richard; Vibha Bhatnagar; Wei Wu
Journal:  Physiol Rev       Date:  2015-01       Impact factor: 37.312

4.  The Concise Guide to PHARMACOLOGY 2013/14: transporters.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

5.  Interaction of H+ with the extracellular and intracellular aspects of hMATE1.

Authors:  Yodying Dangprapai; Stephen H Wright
Journal:  Am J Physiol Renal Physiol       Date:  2011-05-25

Review 6.  The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.

Authors:  Rongbao Zhao; Srinivas Aluri; I David Goldman
Journal:  Mol Aspects Med       Date:  2016-09-21

7.  Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier.

Authors:  Kazuto Yasuda; Cynthia Cline; Peter Vogel; Mihaela Onciu; Soghra Fatima; Brian P Sorrentino; Ranjit K Thirumaran; Sean Ekins; Yoshihiro Urade; Ko Fujimori; Erin G Schuetz
Journal:  Drug Metab Dispos       Date:  2013-01-08       Impact factor: 3.922

8.  Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.

Authors:  Rongbao Zhao; Mitra Najmi; Srinivas Aluri; David C Spray; I David Goldman
Journal:  Mol Pharmacol       Date:  2018-01-11       Impact factor: 4.436

Review 9.  Contribution of tumoral and host solute carriers to clinical drug response.

Authors:  Jason A Sprowl; Torben S Mikkelsen; Hugh Giovinazzo; Alex Sparreboom
Journal:  Drug Resist Updat       Date:  2012-03-28       Impact factor: 18.500

10.  Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.

Authors:  Sita Kugel Desmoulin; Lei Wang; Lisa Polin; Kathryn White; Juiwanna Kushner; Mark Stout; Zhanjun Hou; Christina Cherian; Aleem Gangjee; Larry H Matherly
Journal:  Mol Pharmacol       Date:  2012-06-26       Impact factor: 4.436
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