Literature DB >> 21186280

TMEM16A protein: a new identity for Ca(2+)-dependent Cl⁻ channels.

Loretta Ferrera1, Antonella Caputo, Luis J V Galietta.   

Abstract

Ca(+)-dependent Cl⁻ channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl⁻ secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.

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Year:  2010        PMID: 21186280     DOI: 10.1152/physiol.00030.2010

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN: 1548-9221


  58 in total

Review 1.  International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.

Authors:  Fen Huang; Xiuming Wong; Lily Y Jan
Journal:  Pharmacol Rev       Date:  2011-11-16       Impact factor: 25.468

2.  Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.

Authors:  Wan Namkung; Zhen Yao; Walter E Finkbeiner; A S Verkman
Journal:  FASEB J       Date:  2011-08-11       Impact factor: 5.191

3.  Targeting ion channels for the treatment of gastrointestinal motility disorders.

Authors:  Arthur Beyder; Gianrico Farrugia
Journal:  Therap Adv Gastroenterol       Date:  2012-01       Impact factor: 4.409

4.  Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A.

Authors:  Maiwase Tembo; Katherine L Wozniak; Rachel E Bainbridge; Anne E Carlson
Journal:  J Biol Chem       Date:  2019-07-02       Impact factor: 5.157

5.  Functional reconstitution of a chloride channel bares its soul.

Authors:  H Criss Hartzell; Chelsey Chandler Ruppersburg
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-14       Impact factor: 11.205

Review 6.  Smooth muscle contractile diversity in the control of regional circulations.

Authors:  John J Reho; Xiaoxu Zheng; Steven A Fisher
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-11-01       Impact factor: 4.733

7.  Time for TMEM?

Authors:  Cathy M Fuller
Journal:  J Physiol       Date:  2012-12-01       Impact factor: 5.182

Review 8.  Regulation of transport in the connecting tubule and cortical collecting duct.

Authors:  Alexander Staruschenko
Journal:  Compr Physiol       Date:  2012-04       Impact factor: 9.090

Review 9.  Ion channels in sarcoma: pathophysiology and treatment options.

Authors:  Thiha Aung; Claudia Asam; Silke Haerteis
Journal:  Pflugers Arch       Date:  2019-08-03       Impact factor: 3.657

10.  Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.

Authors:  Tingting Yang; Wayne A Hendrickson; Henry M Colecraft
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-08       Impact factor: 11.205

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