Literature DB >> 19160440

Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants.

B Gopal Reddy1, Jonathan D Silk, Mariolina Salio, Rengarajan Balamurugan, Dawn Shepherd, Gerd Ritter, Vincenzo Cerundolo, Richard R Schmidt.   

Abstract

Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.

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Year:  2009        PMID： 19160440     DOI： 10.1002/cmdc.200800354

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  8 in total

Review 1.  Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant.

Authors:  Neal N Padte; Xiangming Li; Moriya Tsuji; Sandhya Vasan
Journal:  Clin Immunol       Date:  2010-12-24       Impact factor: 3.969

Review 2.  Raising the roof: the preferential pharmacological stimulation of Th1 and th2 responses mediated by NKT cells.

Authors:  James E East; Andrew J Kennedy; Tonya J Webb
Journal:  Med Res Rev       Date:  2012-12-13       Impact factor: 12.944

Review 3.  A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.

Authors:  Sandhya Vasan; Moriya Tsuji
Journal:  Semin Immunol       Date:  2009-12-04       Impact factor: 11.130

Review 4.  Lipid and glycolipid antigens of CD1d-restricted natural killer T cells.

Authors:  Manjunatha M Venkataswamy; Steven A Porcelli
Journal:  Semin Immunol       Date:  2009-11-27       Impact factor: 11.130

5.  Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues.

Authors:  Peter J Jervis; Marie Moulis; John-Paul Jukes; Hemza Ghadbane; Liam R Cox; Vincenzo Cerundolo; Gurdyal S Besra
Journal:  Carbohydr Res       Date:  2012-03-07       Impact factor: 2.104

6.  Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.

Authors:  Justyna Wojno; John-Paul Jukes; Hemza Ghadbane; Dawn Shepherd; Gurdyal S Besra; Vincenzo Cerundolo; Liam R Cox
Journal:  ACS Chem Biol       Date:  2012-02-29       Impact factor: 5.100

Review 7.  Chemistry and Biology of Bioactive Glycolipids of Marine Origin.

Authors:  Iván Cheng-Sánchez; Francisco Sarabia
Journal:  Mar Drugs       Date:  2018-08-22       Impact factor: 5.118

8.  Non-glycosidic compounds can stimulate both human and mouse iNKT cells.

Authors:  John-Paul Jukes; Uzi Gileadi; Hemza Ghadbane; Ting-Fong Yu; Dawn Shepherd; Liam R Cox; Gurdyal S Besra; Vincenzo Cerundolo
Journal:  Eur J Immunol       Date:  2016-03-01       Impact factor: 5.532
  8 in total

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