PURPOSE: To determine whether pulmonary arterial and venous transit times measured by time-resolved magnetic resonance angiography (MRA) can be used as a diagnostic tool for pulmonary arterial hypertension (PAH). MATERIALS AND METHODS: Twelve patients with confirmed PAH and 10 healthy volunteers were scanned with Institutional Review Board (IRB) approval. Time-resolved MRA and 2D phase contrast flow images of the pulmonary vasculature were acquired. Pulmonary arterial and venous transit times (PaTT and PvTT) and pulmonary valve flow (PVF) were obtained. Pulmonary arterial and pulmonary venous blood volumes (PaBV and PvBV) were calculated as the product of flow and transit time. RESULTS: Patients with PAH showed statistically significant increases in PaTT and PvTT (P < 0.0004, P < 0.05, respectively) compared to controls. PaBV (165.2 ± 92.0 mL) was significantly higher in PAH subjects than controls (97.0 ± 47.1 mL) (P < 0.04), whereas PvBV (127.9 ± 148.9 mL) of PAH subjects had no significant increase from those of healthy controls (142.5 ± 104.1 mL) (P < 0.38). CONCLUSION: Pulmonary arterial transit times measured using time-resolved MRA can be used as a simple, noninvasive metric for detection of altered hemodynamics in PAH.
PURPOSE: To determine whether pulmonary arterial and venous transit times measured by time-resolved magnetic resonance angiography (MRA) can be used as a diagnostic tool for pulmonary arterial hypertension (PAH). MATERIALS AND METHODS: Twelve patients with confirmed PAH and 10 healthy volunteers were scanned with Institutional Review Board (IRB) approval. Time-resolved MRA and 2D phase contrast flow images of the pulmonary vasculature were acquired. Pulmonary arterial and venous transit times (PaTT and PvTT) and pulmonary valve flow (PVF) were obtained. Pulmonary arterial and pulmonary venous blood volumes (PaBV and PvBV) were calculated as the product of flow and transit time. RESULTS:Patients with PAH showed statistically significant increases in PaTT and PvTT (P < 0.0004, P < 0.05, respectively) compared to controls. PaBV (165.2 ± 92.0 mL) was significantly higher in PAH subjects than controls (97.0 ± 47.1 mL) (P < 0.04), whereas PvBV (127.9 ± 148.9 mL) of PAH subjects had no significant increase from those of healthy controls (142.5 ± 104.1 mL) (P < 0.38). CONCLUSION: Pulmonary arterial transit times measured using time-resolved MRA can be used as a simple, noninvasive metric for detection of altered hemodynamics in PAH.
Authors: Ty A Cashen; Hyun Jeong; Maulin K Shah; Hem M Bhatt; Wanyong Shin; James C Carr; Matthew T Walker; H Hunt Batjer; Timothy J Carroll Journal: Magn Reson Med Date: 2007-11 Impact factor: 4.668
Authors: Hermann Körperich; Jürgen Gieseke; Hermann Esdorn; Andreas Peterschröder; Romhild Hoogeveen; Peter Barth; Matthias Peuster; Hans Meyer; Samir Sarikouch; Philipp Beerbaum Journal: J Cardiovasc Magn Reson Date: 2007 Impact factor: 5.364
Authors: Sebastian Ley; Christian Fink; Julia Zaporozhan; Mathias M Borst; F Joachim Meyer; Michael Puderbach; Monika Eichinger; Christian Plathow; Ekkehard Grünig; Karl-Friedrich Kreitner; Hans-Ulrich Kauczor Journal: Eur Radiol Date: 2005-07-22 Impact factor: 5.315
Authors: Michael Pienn; Gabor Kovacs; Maria Tscherner; Alexander Avian; Thorsten R Johnson; Peter Kullnig; Rudolf Stollberger; Andrea Olschewski; Horst Olschewski; Zoltán Bálint Journal: Eur Radiol Date: 2013-12-06 Impact factor: 5.315
Authors: Stephen J Riederer; Clifton R Haider; Eric A Borisch; Paul T Weavers; Phillip M Young Journal: J Magn Reson Imaging Date: 2015-06-01 Impact factor: 4.813
Authors: Jenny Louise Bacon; Brendan Patrick Madden; Conor Gissane; Charles Sayer; Sarah Sheard; Ioannis Vlahos Journal: Radiol Cardiothorac Imaging Date: 2020-12-17
Authors: Octavia Bane; Sanjiv J Shah; Michael J Cuttica; Jeremy D Collins; Senthil Selvaraj; Neil R Chatterjee; Christoph Guetter; James C Carr; Timothy J Carroll Journal: Magn Reson Imaging Date: 2015-08-14 Impact factor: 2.546
Authors: Andrew J Swift; Jim M Wild; Scott K Nagle; Alejandro Roldán-Alzate; Christopher J François; Sean Fain; Kevin Johnson; Dave Capener; Edwin J R van Beek; David G Kiely; Kang Wang; Mark L Schiebler Journal: J Thorac Imaging Date: 2014-03 Impact factor: 3.000