Literature DB >> 2117338

FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor.

A Blackham1, R J Griffiths, C Hallam, J Mann, P D Mitchell, A A Norris, W T Simpson.   

Abstract

FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activity in vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.

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Year:  1990        PMID： 2117338     DOI： 10.1007/bf01966309

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  21 in total

1.  Leukotriene B4 and prostaglandin E2 mediate the inflammatory response of rabbit skin to intradermal arachidonic acid.

Authors:  D M Aked; S J Foster
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

2.  The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation.

Authors:  D Aked; S J Foster; A Howarth; M E McCormick; H C Potts
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

3.  Basophils in bronchial asthma with reference to reagin-type allergy.

Authors:  I Kimura; Y Moritani; Y Tanizaki
Journal:  Clin Allergy       Date:  1973-06

Review 4.  Psoriatic science.

Authors:  C M Rowland Payne
Journal:  Br Med J (Clin Res Ed)       Date:  1987-11-07

5.  The effect of BW 540C, a novel anti-inflammatory agent, on ultraviolet-induced physical and histological changes in guinea-pig skin.

Authors:  B Dawson; R L Follenfant; G A Higgs; C Schneider; J R Gibson
Journal:  Br J Dermatol       Date:  1985-07       Impact factor: 9.302

6.  Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C.

Authors:  A Fournier; A W Murray
Journal:  Nature       Date:  1987 Dec 24-31       Impact factor: 49.962

7.  Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

Authors:  H S Penefsky
Journal:  J Biol Chem       Date:  1977-05-10       Impact factor: 5.157

8.  Prostaglandin and leukotriene synthesis in mouse ears inflamed by arachidonic acid.

Authors:  E E Opas; R J Bonney; J L Humes
Journal:  J Invest Dermatol       Date:  1985-04       Impact factor: 8.551

9.  Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents.

Authors:  R P Carlson; L O'Neill-Davis; J Chang; A J Lewis
Journal:  Agents Actions       Date:  1985-12

10.  Cyclosporin A inhibits biological effects of tumor promoting phorbol esters.

Authors:  M Gschwendt; W Kittstein; F Horn; F Marks
Journal:  Biochem Biophys Res Commun       Date:  1985-01-16       Impact factor: 3.575
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  2 in total

1.  Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema.

Authors:  L H Jones; D S Abdalla; J C Freitas
Journal:  Inflamm Res       Date:  1995-09       Impact factor: 4.575

2.  Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO.

Authors:  Kazuko Yoshikawa; Kazuaki Koso; Masumi Shimomura; Masami Tanaka; Hirofumi Yamamoto; Hiroshi Imagawa; Shigenobu Arihara; Toshihiro Hashimoto
Journal:  Molecules       Date:  2013-04-09       Impact factor: 4.411
  2 in total

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