OBJECTIVE: Primary lateral sclerosis (PLS) is a progressive degenerative disorder affecting upper motor neurons and requires a clinical diagnosis. Diffusion tensor imaging (DTI) is a quantitative method for assessing white matter fibre integrity. The purpose of the study was to evaluate the involvement of upper motor neurons by using DTI in PLS. METHODS: A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis. RESULTS: Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells. CONCLUSION: Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS.
OBJECTIVE:Primary lateral sclerosis (PLS) is a progressive degenerative disorder affecting upper motor neurons and requires a clinical diagnosis. Diffusion tensor imaging (DTI) is a quantitative method for assessing white matter fibre integrity. The purpose of the study was to evaluate the involvement of upper motor neurons by using DTI in PLS. METHODS: A patient with PLS was compared with eight age-matched controls. Differences in fractional anisotropy (FA) index were assessed using DTI on a voxel-by-voxel basis. RESULTS: Decreased FA was observed in the proximal part of the pyramidal tract bilaterally, which indicated degeneration of the pyramidal cells. CONCLUSION: Voxel-based DTI could be used as an objective marker for detecting upper motor neuron degeneration in PLS.
Authors: M Bozzali; M Cercignani; F Baglio; G Scotti; E Farina; L Pugnetti; J Ashburner; R Nemni; A Falini Journal: Parkinsonism Relat Disord Date: 2008-03-06 Impact factor: 4.891
Authors: N Le Forestier; T Maisonobe; L Spelle; A Lesort; F Salachas; L Lacomblez; Y Samson; P Bouche; V Meininger Journal: J Neurol Sci Date: 2001-04-01 Impact factor: 3.181
Authors: J Kuipers-Upmeijer; A E de Jager; J M Hew; J W Snoek; T W van Weerden Journal: J Neurol Neurosurg Psychiatry Date: 2001-11 Impact factor: 10.154
Authors: Aziz M Uluğ; Thomas Grünewald; Michael T Lin; Ayeesha K Kamal; Christopher G Filippi; Robert D Zimmerman; M Flint Beal Journal: J Magn Reson Imaging Date: 2004-01 Impact factor: 4.813
Authors: Jeffrey M Statland; Richard J Barohn; Mazen M Dimachkie; Mary Kay Floeter; Hiroshi Mitsumoto Journal: Neurol Clin Date: 2015-09-08 Impact factor: 3.806