PURPOSE: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). MATERIALS AND METHODS: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging. RESULTS: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness. CONCLUSION: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS. Copyright 2003 Wiley-Liss, Inc.
PURPOSE: To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). MATERIALS AND METHODS: Five patients who met clinical criteria for a diagnosis of PLS, and two patients with possible PLS of less than three years duration and eight normal volunteers were studied using MR diffusion tensor imaging. RESULTS: All seven patients showed decreased diffusion anisotropy and increased diffusion constant in the PLIC, with complete separation from a normal control group, including patients early in the course of the illness. CONCLUSION: Quantitative diffusion tensor imaging appears to be a useful test to detect upper motor neuron damage and hence to help to establish the diagnosis of PLS. Copyright 2003 Wiley-Liss, Inc.
Authors: Alexander Unrath; Hans-Peter Müller; Axel Riecker; Albert C Ludolph; Anne-Dorte Sperfeld; Jan Kassubek Journal: Hum Brain Mapp Date: 2010-11 Impact factor: 5.038
Authors: Nobue K Iwata; Justin Y Kwan; Laura E Danielian; John A Butman; Fernanda Tovar-Moll; Elham Bayat; Mary Kay Floeter Journal: Brain Date: 2011-07-28 Impact factor: 13.501
Authors: Joshua P Nickerson; Christopher J Koski; Andrew C Boyer; Heather N Burbank; Rup Tandan; Christopher G Filippi Journal: Klin Neuroradiol Date: 2009-05-23