| Literature DB >> 10698440 |
K Lackey1, M Cory, R Davis, S V Frye, P A Harris, R N Hunter, D K Jung, O B McDonald, R W McNutt, M R Peel, R D Rutkowske, J M Veal, E R Wood.
Abstract
A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and evaluated as cRaf-1 kinase inhibitors. The key features of the molecules were the donor/acceptor motif common to kinase inhibitors and a critical acidic phenol flanked by two substitutions. Diverse 5-position substitutions provided compounds with low nanomolar kinase enzyme inhibition and inhibited the intracellular MAPK pathway.Entities:
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Year: 2000 PMID： 10698440 DOI： 10.1016/s0960-894x(99)00668-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823