OBJECTIVES: Peripheral blood mononuclear cells (PBMCs) increase after acute myocardial infarction (AMI) and infiltrate to the infarct region. However, its impact on left ventricular (LV) remodeling remains unclear. The purpose of the present study was to clarify whether elevated PBMC count contributed to LV remodeling in patients with AMI. SUBJECTS AND METHODS: A total of 131 patients with AMI were recruited. White blood cell (WBC), monocyte, and lymphocyte counts were measured at presentation and every 24h for five days after presentation. The correlation between PBMC count and LV remodeling was evaluated. LV remodeling was defined as an increase of LV end-diastolic volume index ≥ 10% at the 6-month follow-up left ventriculography. RESULTS: Forty-eight patients had LV remodeling. Peak WBC (p=0.008), peak monocyte (p=0.001), and peak PBMC (p<0.001) counts were significantly greater in patients with LV remodeling than those without remodeling. Multivariate analysis revealed the peak PBMC count ≥ 3600/mm(3) was an independent predictor of LV remodeling [relative risk (RR) 3.243, p=0.011]. CONCLUSION: Increased PBMC count is significantly correlated with LV remodeling, thus suggesting that PBMCs play a pivotal role for the development of LV remodeling after AMI.
OBJECTIVES: Peripheral blood mononuclear cells (PBMCs) increase after acute myocardial infarction (AMI) and infiltrate to the infarct region. However, its impact on left ventricular (LV) remodeling remains unclear. The purpose of the present study was to clarify whether elevated PBMC count contributed to LV remodeling in patients with AMI. SUBJECTS AND METHODS: A total of 131 patients with AMI were recruited. White blood cell (WBC), monocyte, and lymphocyte counts were measured at presentation and every 24h for five days after presentation. The correlation between PBMC count and LV remodeling was evaluated. LV remodeling was defined as an increase of LV end-diastolic volume index ≥ 10% at the 6-month follow-up left ventriculography. RESULTS: Forty-eight patients had LV remodeling. Peak WBC (p=0.008), peak monocyte (p=0.001), and peak PBMC (p<0.001) counts were significantly greater in patients with LV remodeling than those without remodeling. Multivariate analysis revealed the peak PBMC count ≥ 3600/mm(3) was an independent predictor of LV remodeling [relative risk (RR) 3.243, p=0.011]. CONCLUSION: Increased PBMC count is significantly correlated with LV remodeling, thus suggesting that PBMCs play a pivotal role for the development of LV remodeling after AMI.
Authors: Dian J Cao; Gabriele G Schiattarella; Elisa Villalobos; Nan Jiang; Herman I May; Tuo Li; Zhijian J Chen; Thomas G Gillette; Joseph A Hill Journal: Circulation Date: 2018-02-01 Impact factor: 29.690
Authors: Florian Leuschner; Philipp J Rauch; Takuya Ueno; Rostic Gorbatov; Brett Marinelli; Won Woo Lee; Partha Dutta; Ying Wei; Clinton Robbins; Yoshiko Iwamoto; Brena Sena; Aleksey Chudnovskiy; Peter Panizzi; Edmund Keliher; John M Higgins; Peter Libby; Michael A Moskowitz; Mikael J Pittet; Filip K Swirski; Ralph Weissleder; Matthias Nahrendorf Journal: J Exp Med Date: 2012-01-02 Impact factor: 14.307
Authors: Mark A Evans; Nicola Smart; Karina N Dubé; Sveva Bollini; James E Clark; Hayley G Evans; Leonie S Taams; Rebecca Richardson; Mathieu Lévesque; Paul Martin; Kevin Mills; Johannes Riegler; Anthony N Price; Mark F Lythgoe; Paul R Riley Journal: Nat Commun Date: 2013 Impact factor: 14.919