| Literature DB >> 21168207 |
Jihong Niu1, Henan Li, Yao Zhang, Jinlan Li, Min Xie, Lingdi Li, Xiaoying Qin, Yazhen Qin, Xiaohuan Guo, Qian Jiang, Yanrong Liu, Shanshan Chen, Xiaojun Huang, Wenling Han, Guorui Ruan.
Abstract
CMTM5 has been shown to exhibit tumor suppressor activities, however, its role in leukemia is unclear. Herein we firstly reported the expression and function of CMTM5 in myeloid leukemia. CMTM5 was down-regulated, or undetectable, in leukemia cell lines and bone marrow cells from leukemia patients with promoter methylation. Ectopic expression of CMTM5-v1 strongly inhibited the proliferation of K562 and MEG-01 cells. In addition, significant negative correlations were observed between CMTM5 and three leukemia-specific fusion genes (AML1-ETO, PML-RARα and BCR/ABL1). CMTM5 expression was up-regulated in patients who had undergone treatment. Therefore, CMTM5 may be involved in the pathomechanism of myeloid leukemias.Entities:
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Year: 2010 PMID： 21168207 DOI： 10.1016/j.leukres.2010.11.023
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156