OBJECTIVE: To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children. STUDY DESIGN: A total of 520 obese children aged 6-18 years were recruited. Their PNPLA3 rs738409 genotypes-CC, CG, or GG-were detected by the 5'-nuclease assay. The effects of the PNPLA3 rs738409 G allele on pediatric NAFLD were evaluated based on liver ultrasonography findings and mean serum alanine aminotransferase levels in these children. RESULTS: NAFLD was present in 19.6% of the obese children. In comparison to the subjects with CC alleles, the risk of NAFLD was increased by 2.96-fold (95% CI, 1.57 to 5.59, P = .0008) in the subjects with CG alleles and by 5.84-fold (95% CI, 2.59 to 13.16; P < .0001) in those with GG alleles. Variant PNPLA3 rs738409 genotypes were associated with increases in mean serum alanine aminotransferase level of 4.77 IU/L (P = .0435) in subjects with CG alleles and of 10.86 IU/L (P < .0001) in those with GG alleles compared with subjects with CC alleles. CONCLUSIONS: The variant PNPLA3 rs738409 genotypes increased the risk of NAFLD in our population of obese Taiwanese children. The effect of the G allele on pediatric NAFLD followed a dominant genetic model.
OBJECTIVE: To test the hypothesis that the presence of the PNPLA3rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children. STUDY DESIGN: A total of 520 obesechildren aged 6-18 years were recruited. Their PNPLA3rs738409 genotypes-CC, CG, or GG-were detected by the 5'-nuclease assay. The effects of the PNPLA3rs738409 G allele on pediatric NAFLD were evaluated based on liver ultrasonography findings and mean serum alanine aminotransferase levels in these children. RESULTS: NAFLD was present in 19.6% of the obesechildren. In comparison to the subjects with CC alleles, the risk of NAFLD was increased by 2.96-fold (95% CI, 1.57 to 5.59, P = .0008) in the subjects with CG alleles and by 5.84-fold (95% CI, 2.59 to 13.16; P < .0001) in those with GG alleles. Variant PNPLA3rs738409 genotypes were associated with increases in mean serum alanine aminotransferase level of 4.77 IU/L (P = .0435) in subjects with CG alleles and of 10.86 IU/L (P < .0001) in those with GG alleles compared with subjects with CC alleles. CONCLUSIONS: The variant PNPLA3rs738409 genotypes increased the risk of NAFLD in our population of obese Taiwanese children. The effect of the G allele on pediatric NAFLD followed a dominant genetic model.
Authors: Julia Wattacheril; Joel E Lavine; Naga P Chalasani; Xiuqing Guo; Soonil Kwon; Jeffrey Schwimmer; Jean P Molleston; Rohit Loomba; Elizabeth M Brunt; Yii-Der Ida Chen; Mark O Goodarzi; Kent D Taylor; Katherine P Yates; James Tonascia; Jerome I Rotter Journal: J Pediatr Date: 2017-09-14 Impact factor: 4.406
Authors: Marta Rorat; Tomasz Jurek; Ernest Kuchar; Leszek Szenborn; Wojciech Golema; Agnieszka Halon Journal: World J Pediatr Date: 2012-12-29 Impact factor: 2.764
Authors: Lucia Pacifico; Claudio Chiesa; Caterina Anania; Antonio De Merulis; John Frederick Osborn; Sara Romaggioli; Eugenio Gaudio Journal: World J Gastroenterol Date: 2014-07-21 Impact factor: 5.742