OBJECTIVE: To study extra- gastric manifestations of H. pylori infection among children in Egypt. METHODS: This case-control study in which thirty [corrected] H pylori positive children were compared to thirty [corrected] H pylori negative children was conducted. Full history taking, clinical examination, CBC, serum iron, serum ferritin in addition to H pylori antibody testing were performed. RESULTS: Mean hemoglobin, MCV, MCH, serum iron and serum ferritin were all less in seropositive patients but these were statistically non significant. Iron deficiency (ID) was defined as serum ferritin less than 12 ng/ml; and Iron deficiency anemia (IDA) as hemoglobin less than 11 g/dL in addition to ID. Seropositive patients showed increased frequency of ID and IDA and this was statistically significant (0.003 & 0.000 respectively). There was no statistically significant difference as regards the platelet counts of the two groups or the presence of skin disorders or the gender. CONCLUSIONS: There is increased incidence of ID and IDA among H pylori positive children. This needs to be confirmed by larger therapeutic randomized controlled trials. The hematological response to eradication therapy needs to be further studied.
OBJECTIVE: To study extra- gastric manifestations of H. pyloriinfection among children in Egypt. METHODS: This case-control study in which thirty [corrected] H pylori positive children were compared to thirty [corrected] H pylori negative children was conducted. Full history taking, clinical examination, CBC, serum iron, serum ferritin in addition to H pylori antibody testing were performed. RESULTS: Mean hemoglobin, MCV, MCH, serum iron and serum ferritin were all less in seropositive patients but these were statistically non significant. Iron deficiency (ID) was defined as serum ferritin less than 12 ng/ml; and Iron deficiency anemia (IDA) as hemoglobin less than 11 g/dL in addition to ID. Seropositive patients showed increased frequency of ID and IDA and this was statistically significant (0.003 & 0.000 respectively). There was no statistically significant difference as regards the platelet counts of the two groups or the presence of skin disorders or the gender. CONCLUSIONS: There is increased incidence of ID and IDA among H pylori positive children. This needs to be confirmed by larger therapeutic randomized controlled trials. The hematological response to eradication therapy needs to be further studied.
Authors: Bradford D Gessner; Henry C Baggett; Pam T Muth; Eitel Dunaway; Benjamin D Gold; Ziding Feng; Alan J Parkinson Journal: J Infect Dis Date: 2006-01-12 Impact factor: 5.226
Authors: Manisha Singh; Kashi N Prasad; Surender K Yachha; Ashish Saxena; Narendra Krishnani Journal: Trans R Soc Trop Med Hyg Date: 2005-11-02 Impact factor: 2.184
Authors: D Y Graham; E Adam; G T Reddy; J P Agarwal; R Agarwal; D J Evans; H M Malaty; D G Evans Journal: Dig Dis Sci Date: 1991-08 Impact factor: 3.199
Authors: Soheir B Fayed; Mohamed I Aref; Hanan M Fathy; Soha M Abd El Dayem; Nahed A Emara; Ali Maklof; Amer Shafik Journal: J Trop Pediatr Date: 2007-09-30 Impact factor: 1.165