Ibrahim H Galadari1, Mohamed Omar Sheriff. 1. Faculty of Medicine and Health Sciences, Dermatology Department, United Arab Emirates University and Al Ain Hospital, Al Ain, United Arab Emirate. galadari@email.com
Abstract
INTRODUCTION: Helicobacter pylori, a common cause of gastritis and peptic ulcer, has been associated with several extragastrointestinal diseases. Many studies have shown a positive relation between H. pylori infection and both chronic idiopathic urticaria and atopic dermatitis. METHODS: The study included 20 patients diagnosed with chronic idiopathic urticaria and 20 with atopic dermatitis. A randomized sample of 20 healthy individuals was selected as a control group. H. pylori infection was assessed using the C-urea breath test, and anti-H. pyloriIgG antibody titers were determined by enzyme-linked immunosorbent assay. RESULTS: In the chronic idiopathic urticaria group, the urea breath test titer was positive in 75% of patients, and anti-IgG antibodies were also detected in 75% of patients. In the atopic dermatitis group, titer was positive in 70% and antibodies were detected in 65% of patients, while in the control group, the urea breath test titer was positive in 55% and antibodies were seen in 20% of patients. This difference was statistically highly significant (p < 0.001) in the case of anti-H. pylori antibodies in relation to chronic idiopathic urticaria and significant (p < 0.05) in the case of atopic dermatitis. CONCLUSIONS: These results provide some evidence of a relationship between H. pylori infection and both chronic idiopathic urticaria and atopic dermatitis. Treatment of infection demonstrated by reduction in C-urea breath test and anti-H. pylori antibody titers resulted in partial improvement of clinical symptoms in patients with atopic dermatitis.
RCT Entities:
INTRODUCTION:Helicobacter pylori, a common cause of gastritis and peptic ulcer, has been associated with several extragastrointestinal diseases. Many studies have shown a positive relation between H. pyloriinfection and both chronic idiopathic urticaria and atopic dermatitis. METHODS: The study included 20 patients diagnosed with chronic idiopathic urticaria and 20 with atopic dermatitis. A randomized sample of 20 healthy individuals was selected as a control group. H. pyloriinfection was assessed using the C-urea breath test, and anti-H. pylori IgG antibody titers were determined by enzyme-linked immunosorbent assay. RESULTS: In the chronic idiopathic urticaria group, the urea breath test titer was positive in 75% of patients, and anti-IgG antibodies were also detected in 75% of patients. In the atopic dermatitis group, titer was positive in 70% and antibodies were detected in 65% of patients, while in the control group, the urea breath test titer was positive in 55% and antibodies were seen in 20% of patients. This difference was statistically highly significant (p < 0.001) in the case of anti-H. pylori antibodies in relation to chronic idiopathic urticaria and significant (p < 0.05) in the case of atopic dermatitis. CONCLUSIONS: These results provide some evidence of a relationship between H. pyloriinfection and both chronic idiopathic urticaria and atopic dermatitis. Treatment of infection demonstrated by reduction in C-urea breath test and anti-H. pylori antibody titers resulted in partial improvement of clinical symptoms in patients with atopic dermatitis.
Authors: Ag Gravina; A Federico; E Ruocco; A Lo Schiavo; M Masarone; C Tuccillo; F Peccerillo; A Miranda; L Romano; C de Sio; I de Sio; M Persico; V Ruocco; G Riegler; C Loguercio; M Romano Journal: United European Gastroenterol J Date: 2015-02 Impact factor: 4.623
Authors: Marcella Pedullà; Vincenzo Fierro; Ester Del Tufo; Rossella Alfano; Maria Triassi; Laura Perrone Journal: United European Gastroenterol J Date: 2014-08 Impact factor: 4.623
Authors: Antonietta Gerarda Gravina; Rocco Maurizio Zagari; Cristiana De Musis; Lorenzo Romano; Carmelina Loguercio; Marco Romano Journal: World J Gastroenterol Date: 2018-08-07 Impact factor: 5.742