| Literature DB >> 21163632 |
V Kuete1, S Alibert-Franco, K O Eyong, B Ngameni, G N Folefoc, J R Nguemeving, J G Tangmouo, G W Fotso, J Komguem, B M W Ouahouo, J-M Bolla, J Chevalier, B T Ngadjui, A E Nkengfack, J-M Pagès.
Abstract
The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.Entities:
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Year: 2010 PMID： 21163632 DOI： 10.1016/j.ijantimicag.2010.10.020
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283