BACKGROUND: Non-tuberculous mycobacteria (NTM) cause infections in patients with smoking-related chronic lung diseases and also in non-smoking healthy elderly women. We analyzed the clinical symptoms, underlying diseases and mortality in patients with NTM culture findings, with special emphasis on smoking status. METHODS: A total of 120 consecutive adult HIV-negative patients with NTM isolation were followed between 1990 and 1998 by retrieving data from their medical records for a period of at least 4 y, until 8 June 2006. Their clinical pictures and outcomes were analysed according to smoking status. RESULTS: In this study, 42% of the patients had never smoked. Females accounted for 72% of non-smokers, but only 30% of smokers (p < 0.001). Mycobacterium avium complex (MAC) accounted for 72% of all isolates in non-smokers and 41% in smokers (p = 0.001). Furthermore, 28% of non-smokers and 19% of smokers had no previous pulmonary diseases (p = 0.223). In nearly half of all patients (48%), symptoms of NTM infection started within a year prior to NTM isolation. Smokers had a higher risk of mortality compared to non-smokers (hazard ratio 1.64, p = 0.049), though this was not found after adjusting for underlying diseases. No fatal underlying diseases were found for 82% of non-smokers and 59% of smokers (p < 0.01). CONCLUSIONS: Non-smokers with NTM isolates had fewer previous lung diseases but had a higher incidence of MAC and bronchiectasis. Time from symptoms to NTM isolation was shorter than previously reported.
BACKGROUND:Non-tuberculous mycobacteria (NTM) cause infections in patients with smoking-related chronic lung diseases and also in non-smoking healthy elderly women. We analyzed the clinical symptoms, underlying diseases and mortality in patients with NTM culture findings, with special emphasis on smoking status. METHODS: A total of 120 consecutive adult HIV-negative patients with NTM isolation were followed between 1990 and 1998 by retrieving data from their medical records for a period of at least 4 y, until 8 June 2006. Their clinical pictures and outcomes were analysed according to smoking status. RESULTS: In this study, 42% of the patients had never smoked. Females accounted for 72% of non-smokers, but only 30% of smokers (p < 0.001). Mycobacterium avium complex (MAC) accounted for 72% of all isolates in non-smokers and 41% in smokers (p = 0.001). Furthermore, 28% of non-smokers and 19% of smokers had no previous pulmonary diseases (p = 0.223). In nearly half of all patients (48%), symptoms of NTM infection started within a year prior to NTM isolation. Smokers had a higher risk of mortality compared to non-smokers (hazard ratio 1.64, p = 0.049), though this was not found after adjusting for underlying diseases. No fatal underlying diseases were found for 82% of non-smokers and 59% of smokers (p < 0.01). CONCLUSIONS: Non-smokers with NTM isolates had fewer previous lung diseases but had a higher incidence of MAC and bronchiectasis. Time from symptoms to NTM isolation was shorter than previously reported.
Authors: M Fleshner; K N Olivier; P A Shaw; J Adjemian; S Strollo; R J Claypool; L Folio; A Zelazny; S M Holland; D R Prevots Journal: Int J Tuberc Lung Dis Date: 2016-05 Impact factor: 2.373
Authors: James Graham; Christina E Wong; Joshua Day; Elizabeth McFaddin; Urs Ochsner; Teresa Hoang; Casey L Young; Wendy Ribble; Mary A DeGroote; Thale Jarvis; Xicheng Sun Journal: Bioorg Med Chem Lett Date: 2018-08-25 Impact factor: 2.940
Authors: H Kotilainen; V Valtonen; P Tukiainen; T Poussa; J Eskola; A Järvinen Journal: Eur J Clin Microbiol Infect Dis Date: 2015-07-09 Impact factor: 3.267
Authors: Hannele Kotilainen; Marja-Liisa Lokki; Riitta Paakkanen; Mikko Seppänen; Pentti Tukiainen; Seppo Meri; Tuija Poussa; Jussi Eskola; Ville Valtonen; Asko Järvinen Journal: PLoS One Date: 2014-03-17 Impact factor: 3.240