| Literature DB >> 21160720 |
Panayotis Ioannides1, Dimitris Karacostas.
Abstract
Human prion disease is a rare, uniformly fatal neurodegenerative disorder.Its precise pathogenesis is obscure. The clinical profile of the disease differs among its various forms. There are no definitive diagnostic tests (except for brain biopsy) or proven treatment. To increase the clinical diagnostic sensitivity and specificity, three laboratory tests, including electroencephalogram, cerebrospinal fluid testing for 14-3-3 protein, and magnetic resonance imaging, are currently used. Additionally, proton magnetic resonance spectroscopy, positron emission tomography and single photon emission computed tomography can provide interesting and novel results in the research of human prion disease.Entities:
Keywords: Creutzfeldt-Jakob disease; Human prion disease; Magnetic resonance imaging; Neuroimaging
Year: 2009 PMID: 21160720 PMCID: PMC2999305 DOI: 10.4329/wjr.v1.i1.45
Source DB: PubMed Journal: World J Radiol ISSN: 1949-8470