OBJECTIVES: To report the results from the Brazilian database on multiple sclerosis (MS) and pregnancy. METHODS: Retrospective data from MS patients who became pregnant at any time of their disease were sent to a Brazilian database, using a specific file for this purpose. RESULTS: Data on 128 women (142 pregnancies) from 30 neurologists working in 21 cities in Brazil were collected. Patients' average age at pregnancy was 29.8 years (range 16-42). EDSS at start of pregnancy was 1.5±1.4; and the relapse rate in the year preceding pregnancy was 1.2±1.5. Exposure to medication at any time during pregnancy was high (69.7%): 48.6% to interferon beta; 14.1% to glatiramer acetate; and 7% to other immunomodulatory and immunosuppressive drugs. There was a significant decrease in relapse rate during pregnancy. The prevalence of complications was relatively low, with 4.9% of obstetric and 1.4% neonatal unfavorable outcomes. CONCLUSIONS: Our patients had low degrees of disability, short histories of disease, high drug exposure, and relatively high relapse rate in the year previous to pregnancy. Obstetric and neonatal outcomes were successful in over 90% of our patients.
OBJECTIVES: To report the results from the Brazilian database on multiple sclerosis (MS) and pregnancy. METHODS: Retrospective data from MSpatients who became pregnant at any time of their disease were sent to a Brazilian database, using a specific file for this purpose. RESULTS: Data on 128 women (142 pregnancies) from 30 neurologists working in 21 cities in Brazil were collected. Patients' average age at pregnancy was 29.8 years (range 16-42). EDSS at start of pregnancy was 1.5±1.4; and the relapse rate in the year preceding pregnancy was 1.2±1.5. Exposure to medication at any time during pregnancy was high (69.7%): 48.6% to interferon beta; 14.1% to glatiramer acetate; and 7% to other immunomodulatory and immunosuppressive drugs. There was a significant decrease in relapse rate during pregnancy. The prevalence of complications was relatively low, with 4.9% of obstetric and 1.4% neonatal unfavorable outcomes. CONCLUSIONS: Our patients had low degrees of disability, short histories of disease, high drug exposure, and relatively high relapse rate in the year previous to pregnancy. Obstetric and neonatal outcomes were successful in over 90% of our patients.
Authors: Yara D Fragoso; Tarso Adoni; Soniza V Alves-Leon; Nério D Azambuja; Amilton A Barreira; Joseph B B Brooks; Denise S D Carneiro; Margarete J Carvalho; Rinaldo Claudino; Elizabeth R Comini-Frota; Renan B Domingues; Alessandro Finkelzstejn; Paulo D Gama; Maria C B Giacomo; Sidney Gomes; Marcus V M Goncalves; Anderson K Grzesiuk; Damacio R Kaimen-Maciel; Maria F Mendes; Nivea M O Morales; Rogério R Morales; Andre Muniz; Regina M Papais-Alvarenga; Monica K F Parolin; Sonia B F Ribeiro; Heloisa H Ruocco; Fabio Siquineli; Elza D Tosta Journal: CNS Drugs Date: 2013-11 Impact factor: 5.749
Authors: Ellen Lu; Yinshan Zhao; Feng Zhu; Mia L van der Kop; Anne Synnes; Leanne Dahlgren; A Dessa Sadovnick; Ana-Luiza Sayao; Helen Tremlett Journal: Neurology Date: 2013-01-09 Impact factor: 9.910