OBJECTIVE: Low circulating levels of testosterone and sex-hormone-binding globulin (SHBG) are associated with increased cardiovascular risk in men. This association may be partially mediated through changes in glucose metabolism, but relatively few data are available on the relationship between sex hormones and markers of long-term glycaemia. We assessed the associations of endogenous testosterone and SHBG with glycated haemoglobin (HbA(1c) ) in men. DESIGN AND SUBJECTS: Cross-sectional study of 1292 men from the Norfolk population of European Prospective Investigation into Cancer (EPIC-Norfolk). MEASUREMENTS: Glycated haemoglobin, total testosterone (TT) and SHBG levels were measured, and free testosterone (FT) levels were calculated. Multiple linear regression models were used to assess the associations of TT, SHBG and FT with HbA(1c). RESULTS: Men with diabetes had lower testosterone and SHBG levels. In non-diabetic men, HbA(1c) levels were inversely associated with TT and calculated FT independently of age, body mass index, smoking, alcohol consumption and physical activity. The adjusted change in HbA(1c) was 0·055 (95% CI 0·025; 0·085) per standard deviation (SD) decrease in TT and 0·041 (95% CI 0·010; 0·073) per SD decrease in calculated FT, respectively. SHBG levels were inversely associated with HbA(1c) after multivariable adjustment (β = 0·038 per SD decrease (95% CI 0·004; 0·071)). CONCLUSIONS: In middle-aged and older men, low endogenous testosterone and SHBG levels are associated with glycaemia, even below the threshold for diabetes. Further studies are needed to determine the effects of interventions that raise testosterone levels in men having increased HbA(1c) and subnormal testosterone levels.
OBJECTIVE: Low circulating levels of testosterone and sex-hormone-binding globulin (SHBG) are associated with increased cardiovascular risk in men. This association may be partially mediated through changes in glucose metabolism, but relatively few data are available on the relationship between sex hormones and markers of long-term glycaemia. We assessed the associations of endogenous testosterone and SHBG with glycated haemoglobin (HbA(1c) ) in men. DESIGN AND SUBJECTS: Cross-sectional study of 1292 men from the Norfolk population of European Prospective Investigation into Cancer (EPIC-Norfolk). MEASUREMENTS: Glycated haemoglobin, total testosterone (TT) and SHBG levels were measured, and free testosterone (FT) levels were calculated. Multiple linear regression models were used to assess the associations of TT, SHBG and FT with HbA(1c). RESULTS: Men with diabetes had lower testosterone and SHBG levels. In non-diabetic men, HbA(1c) levels were inversely associated with TT and calculated FT independently of age, body mass index, smoking, alcohol consumption and physical activity. The adjusted change in HbA(1c) was 0·055 (95% CI 0·025; 0·085) per standard deviation (SD) decrease in TT and 0·041 (95% CI 0·010; 0·073) per SD decrease in calculated FT, respectively. SHBG levels were inversely associated with HbA(1c) after multivariable adjustment (β = 0·038 per SD decrease (95% CI 0·004; 0·071)). CONCLUSIONS: In middle-aged and older men, low endogenous testosterone and SHBG levels are associated with glycaemia, even below the threshold for diabetes. Further studies are needed to determine the effects of interventions that raise testosterone levels in men having increased HbA(1c) and subnormal testosterone levels.
Authors: K J Mather; C Kim; C A Christophi; V R Aroda; W C Knowler; S E Edelstein; J C Florez; F Labrie; S E Kahn; R B Goldberg; E Barrett-Connor Journal: J Clin Endocrinol Metab Date: 2015-07-22 Impact factor: 5.958
Authors: Jessica Santana de Oliveira; Alluanan Adelson do Nascimento Silva; Fernanda Carolina Ribeiro Dias; Elizabeth Lopes de Oliveira; Emanuel Felipe de Oliveira Filho; Pierre Castro Soares; Catarina Michelle de Oliveira Ferreira; Valdemiro Amaro da Silva Junior Journal: Int J Exp Pathol Date: 2022-06-23 Impact factor: 2.793
Authors: Mary Turyk; Giamila Fantuzzi; Victoria Persky; Sally Freels; Anissa Lambertino; Maria Pini; Davina H Rhodes; Henry A Anderson Journal: Environ Res Date: 2015-04-22 Impact factor: 6.498
Authors: Molly M Shores; Alice M Arnold; Mary L Biggs; W T Longstreth; Nicholas L Smith; Jorge R Kizer; Anne R Cappola; Calvin H Hirsch; Brett T Marck; Alvin M Matsumoto Journal: Clin Endocrinol (Oxf) Date: 2014-05-05 Impact factor: 3.478
Authors: Lawrence D Hayes; Fergal M Grace; Nick Sculthorpe; Peter Herbert; John Wt Ratcliffe; Liam P Kilduff; Julien S Baker Journal: Springerplus Date: 2013-01-22