Literature DB >> 211586

Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries.

A L Betz, G W Goldstein.   

Abstract

Capillary endothelial cells isolated from rat brain exhibit Na+-dependent uptake of the neutral amino acid analog alpha-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the antiluminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.

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Year:  1978        PMID： 211586     DOI： 10.1126/science.211586

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  53 in total

Review 1.  Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.

Authors:  J B Van Bree; A G De Boer; M Danhof; D D Breimer
Journal:  Pharm Weekbl Sci       Date:  1992-12-11

2.  Deltorphin transport across the blood-brain barrier.

Authors:  A Fiori; P Cardelli; L Negri; M R Savi; R Strom; V Erspamer
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

Review 3.  Apicobasal polarity of brain endothelial cells.

Authors:  Thomas Worzfeld; Markus Schwaninger
Journal:  J Cereb Blood Flow Metab       Date:  2015-10-06       Impact factor: 6.200

Review 4.  Ultracytochemical study of capillary Ca2+-ATPase activity in brain edema.

Authors:  K Kawai; H Takahashi; F Ikuta
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

Review 5.  Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology.

Authors:  Tetsuya Terasaki; Sumio Ohtsuki
Journal:  NeuroRx       Date:  2005-01

6.  Biomedical Technologies for in vitro Screening and Controlled Delivery of Neuroactive Compounds.

Authors:  John P Frampton; Michael L Shuler; William Shain; Matthew R Hynd
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2008

Review 7.  Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy.

Authors:  Eain M Cornford; Shigeyo Hyman
Journal:  NeuroRx       Date:  2005-01

8.  The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach.

Authors:  Y Wang; D F Welty
Journal:  Pharm Res       Date:  1996-03       Impact factor: 4.200

9.  Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice.

Authors:  A W Vorbrodt; A S Lossinsky; H M Wisniewski; R C Moretz; L Iwanowski
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088

Review 10.  11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas.

Authors:  Tarun Singhal; Tanjore K Narayanan; Viney Jain; Jogeshwar Mukherjee; Joseph Mantil
Journal:  Mol Imaging Biol       Date:  2007-10-24       Impact factor: 3.488
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