Literature DB >> 26661193

Apicobasal polarity of brain endothelial cells.

Thomas Worzfeld1, Markus Schwaninger2.   

Abstract

Normal brain homeostasis depends on the integrity of the blood-brain barrier that controls the access of nutrients, humoral factors, and immune cells to the CNS. The blood-brain barrier is composed mainly of brain endothelial cells. Forming the interface between two compartments, they are highly polarized. Apical/luminal and basolateral/abluminal membranes differ in their lipid and (glyco-)protein composition, allowing brain endothelial cells to secrete or transport soluble factors in a polarized manner and to maintain blood flow. Here, we summarize the basic concepts of apicobasal cell polarity in brain endothelial cells. To address potential molecular mechanisms underlying apicobasal polarity in brain endothelial cells, we draw on investigations in epithelial cells and discuss how polarity may go awry in neurological diseases.
© The Author(s) 2015.

Entities:  

Keywords:  Crumbs; Par complex; Polarized secretion; cerebral cavernous malformations; scribble

Mesh：

Year:  2015        PMID： 26661193      PMCID： PMC4759676          DOI： 10.1177/0271678X15608644

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  199 in total

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