| Literature DB >> 211583 |
W T London, S A Houff, D L Madden, D A Fuccillo, M Gravell, W C Wallen, A E Palmer, J L Sever, B L Padgett, D L Walker, G M ZuRhein, T Ohashi.
Abstract
Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.Entities:
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Year: 1978 PMID： 211583 DOI： 10.1126/science.211583
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728