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Literature DB >> 21156937

Intersecting pathways in cell biology.

Abstract

The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus, defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest. An emerging link between these processes is a family of proteins called intersectins (ITSNs). These multidomain proteins serve as scaffolds in the assembly of endocytic vesicles and also regulate components of various signaling pathways, including kinases, guanosine triphosphatases, and ubiquitin ligases. This review summarizes research on the role of ITSNs in regulating both endocytic and signal transduction pathways, discusses the link between ITSNs and human disease, and highlights future directions in the study of ITSNs.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 21156937 PMCID： PMC3012378 DOI： 10.1126/scisignal.3152re10

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

95 in total

1. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?

Authors: M Okamoto; S Schoch; T C Südhof
Journal: J Biol Chem Date: 1999-06-25 Impact factor: 5.157

2. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.

Authors: A S Sengar; W Wang; J Bishay; S Cohen; S E Egan
Journal: EMBO J Date: 1999-03-01 Impact factor: 11.598

3. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.

Authors: N K Hussain; M Yamabhai; A R Ramjaun; A M Guy; D Baranes; J P O'Bryan; C J Der; B K Kay; P S McPherson
Journal: J Biol Chem Date: 1999-05-28 Impact factor: 5.157

4. Phosphoproteomic analysis of the developing mouse brain.

Authors: Bryan A Ballif; Judit Villén; Sean A Beausoleil; Daniel Schwartz; Steven P Gygi
Journal: Mol Cell Proteomics Date: 2004-09-02 Impact factor: 5.911

5. Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery.

Authors: B K Kay; M Yamabhai; B Wendland; S D Emr
Journal: Protein Sci Date: 1999-02 Impact factor: 6.725

6. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

Authors: T Tsukazaki; T A Chiang; A F Davison; L Attisano; J L Wrana
Journal: Cell Date: 1998-12-11 Impact factor: 41.582

7. Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1-->q22.2.

Authors: M Guipponi; H S Scott; M Hattori; K Ishii; Y Sakaki; S E Antonarakis
Journal: Cytogenet Cell Genet Date: 1998

8. Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.

Authors: C Pucharcós; J J Fuentes; C Casas; S de la Luna; S Alcántara; M L Arbonés; E Soriano; X Estivill; M Pritchard
Journal: Eur J Hum Genet Date: 1999-09 Impact factor: 4.246

Review 9. Endocytosis proteins and cancer: a potential link?

Authors: S Floyd; P De Camilli
Journal: Trends Cell Biol Date: 1998-08 Impact factor: 20.808

10. Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.

Authors: M Yamabhai; N G Hoffman; N L Hardison; P S McPherson; L Castagnoli; G Cesareni; B K Kay
Journal: J Biol Chem Date: 1998-11-20 Impact factor: 5.157

21 in total

1. Fast neurotransmitter release regulated by the endocytic scaffold intersectin.

Authors: Takeshi Sakaba; Natalia L Kononenko; Jelena Bacetic; Arndt Pechstein; Jan Schmoranzer; Lijun Yao; Holger Barth; Oleg Shupliakov; Oliver Kobler; Klaus Aktories; Volker Haucke
Journal: Proc Natl Acad Sci U S A Date: 2013-04-30 Impact factor: 11.205

Review 2. Intersectin scaffold proteins and their role in cell signaling and endocytosis.

Authors: Erika Herrero-Garcia; John P O'Bryan
Journal: Biochim Biophys Acta Mol Cell Res Date: 2016-10-12 Impact factor: 4.739

3. Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice.

Authors: Jamie Harris; Erika Herrero-Garcia; Angela Russo; Andre Kajdacsy-Balla; John P O'Bryan; Bill Chiu
Journal: J Pediatr Hematol Oncol Date: 2017-11 Impact factor: 1.289

4. A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.

Authors: Tomonori Taniguchi; Shigeru Tanaka; Ayumi Ishii; Miyuki Watanabe; Noriko Fujitani; Ayusa Sugeo; Shuhei Gotoh; Takeshi Ohta; Mineyoshi Hiyoshi; Hideki Matsuzaki; Norio Sakai; Hiroaki Konishi
Journal: J Biol Chem Date: 2013-09-03 Impact factor: 5.157

5. Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.

Authors: Mustafa Nazir Okur; Jolene Ooi; Chee Wai Fong; Natalia Martinez; Carlota Garcia-Dominguez; Jose M Rojas; Graeme Guy; John P O'Bryan
Journal: Mol Cell Biol Date: 2011-12-12 Impact factor: 4.272

6. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.

Authors: Michael P Hunter; Marianela Nelson; Michael Kurzer; Xuerong Wang; Richard J Kryscio; Elizabeth Head; Graziano Pinna; John P O'Bryan
Journal: Neuroreport Date: 2011-10-26 Impact factor: 1.837

7. Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans.

Authors: Gui Shen; Erxun Zhou; J Andrew Alspaugh; Ping Wang
Journal: Eukaryot Cell Date: 2012-02-10