Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.

Literature DB >> 21156891

Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.

Aleksey Kazmin¹, Renee C Wong, Mathew Sermer, Gideon Koren.

Abstract

QUESTION: What is the current evidence regarding the association between hemorrhagic disease of the newborn and maternal use of hepatic enzyme-inducing antiepileptic drugs (eg, carbamazepine, phenobarbitone, topiramate)? ANSWER: Women with epilepsy who take enzyme-inducing antiepileptic drugs should be advised that there is no adequate evidence to support or refute taking vitamin K in late pregnancy to prevent bleeding complications in a newborn.

Entities: Chemical Disease Species

Mesh：

Substances：
Anticonvulsants
Vitamin K

Year: 2010 PMID： 21156891 PMCID： PMC3001920

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

11 in total

Review 1. Vitamin K prophylaxis--a useful public health measure?

Authors: R von Kries
Journal: Paediatr Perinat Epidemiol Date: 1992-01 Impact factor: 3.980

Review 2. Vitamin K.

Authors: M J Shearer
Journal: Lancet Date: 1995-01-28 Impact factor: 79.321

3. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology.

Authors:
Journal: Epilepsia Date: 1998-11 Impact factor: 5.864

4. Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.

Authors: K R Mountain; J Hirsh; A S Gallus
Journal: Lancet Date: 1970-02-07 Impact factor: 79.321

5. Transplacental vitamin K prevents haemorrhagic disease of infant of epileptic mother.

Authors: M F Deblay; P Vert; M Andre; F Marchal
Journal: Lancet Date: 1982-05-29 Impact factor: 79.321

6. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate.

Authors: Erja Kaaja; Risto Kaaja; Riitta Matila; Vilho Hiilesmaa
Journal: Neurology Date: 2002-02-26 Impact factor: 9.910

7. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?

Authors: Sophie Choulika; Eric Grabowski; Lewis B Holmes
Journal: Am J Obstet Gynecol Date: 2004-04 Impact factor: 8.661

Review 8. Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society.

Authors: C L Harden; P B Pennell; B S Koppel; C A Hovinga; B Gidal; K J Meador; J Hopp; T Y Ting; W A Hauser; D Thurman; P W Kaplan; J N Robinson; J A French; S Wiebe; A N Wilner; B Vazquez; L Holmes; A Krumholz; R Finnell; P O Shafer; C Le Guen
Journal: Neurology Date: 2009-04-27 Impact factor: 9.910

Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.

Review 1. Vitamin K prophylaxis--a useful public health measure?

Review 2. Vitamin K.

3. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology.

4. Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.

5. Transplacental vitamin K prevents haemorrhagic disease of infant of epileptic mother.

6. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate.

7. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?

9. Haemorrhagic disease of the newborn in the British Isles: two year prospective study.

Review 10. Vitamin K in neonates: how to administer, when and to whom.

Review 1. Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges.

2. Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis.