Literature DB >> 15118607

Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants?

Sophie Choulika1, Eric Grabowski, Lewis B Holmes.   

Abstract

The objective of this cohort study of a consecutive sample of infants exposed during pregnancy to anticonvulsant drugs was to determine if the mother received late pregnancy prophylaxis with vitamin K, and if any infants had signs of hemorrhagic disease. The medical records of 204 neonates exposed to anticonvulsant drugs in utero and 77 unexposed control neonates were retrospectively reviewed. No hemorrhagic disease was observed, and the incidence of bleeding tendencies was not higher in infants exposed to these drugs compared with control infants, despite no prenatal vitamin K supplementation in all but 1 epileptic woman.

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Year:  2004        PMID： 15118607     DOI： 10.1016/j.ajog.2004.01.041

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN： 0002-9378            Impact factor:   8.661


  7 in total

1.  Managing epilepsy during pregnancy: assessing risk and optimizing care.

Authors:  Kaarkuzhali Babu Krishnamurthy
Journal:  Curr Treat Options Neurol       Date:  2012-08       Impact factor: 3.598

Review 2.  Management of epilepsy in women of childbearing age: practical recommendations.

Authors:  Barbara Tettenborn
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

3.  Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.

Authors:  Aleksey Kazmin; Renee C Wong; Mathew Sermer; Gideon Koren
Journal:  Can Fam Physician       Date:  2010-12       Impact factor: 3.275

Review 4.  Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide.

Authors:  Bruna Nucera; Francesco Brigo; Eugen Trinka; Gudrun Kalss
Journal:  Ther Adv Neurol Disord       Date:  2022-06-11       Impact factor: 6.430

Review 5.  Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society.

Authors:  C L Harden; P B Pennell; B S Koppel; C A Hovinga; B Gidal; K J Meador; J Hopp; T Y Ting; W A Hauser; D Thurman; P W Kaplan; J N Robinson; J A French; S Wiebe; A N Wilner; B Vazquez; L Holmes; A Krumholz; R Finnell; P O Shafer; C Le Guen
Journal:  Neurology       Date:  2009-04-27       Impact factor: 9.910

6.  Anticonvulsants and the risk of perinatal bleeding complications: A pregnancy cohort study.

Authors:  Alice Panchaud; Jacqueline M Cohen; Elisabetta Patorno; Krista F Huybrechts; Rishi J Desai; Kathryn J Gray; Helen Mogun; Sonia Hernandez-Diaz; Brian T Bateman
Journal:  Neurology       Date:  2018-07-06       Impact factor: 9.910

7.  Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis.

Authors:  Sadequa Shahrook; Erika Ota; Nobutsugu Hanada; Kimi Sawada; Rintaro Mori
Journal:  Sci Rep       Date:  2018-07-30       Impact factor: 4.379
  7 in total

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