Literature DB >> 21155623

Toxic effects of the easily avoidable phthalates and parabens.

Walter J Crinnion1.   

Abstract

Some environmental toxins like DDT and other chlorinated compounds accumulate in the body because of their fat-soluble nature. Other compounds do not stay long in the body, but still cause toxic effects during the time they are present. For serious health problems to arise, exposure to these rapidly-clearing compounds must occur on a daily basis. Two such classes of compounds are the phthalate plasticizers and parabens, both of which are used in many personal care products, some medications, and even foods and food preservation. The phthalates are commonly found in foods and household dust. Even though they have relatively short half-lives in humans, phthalates have been associated with a number of serious health problems, including infertility, testicular dysgenesis, obesity, asthma, and allergies, as well as leiomyomas and breast cancer. Parabens, which can be dermally absorbed, are present in many cosmetic products, including antiperspirants. Their estrogenicity and tissue presence are a cause for concern regarding breast cancer. Fortunately, these compounds are relatively easy to avoid and such steps can result in dramatic reductions of urinary levels of these compounds.

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Year:  2010        PMID: 21155623

Source DB:  PubMed          Journal:  Altern Med Rev        ISSN: 1089-5159


  26 in total

Review 1.  Cosmetics as endocrine disruptors: are they a health risk?

Authors:  Polyxeni Nicolopoulou-Stamati; Luc Hens; Annie J Sasco
Journal:  Rev Endocr Metab Disord       Date:  2015-12       Impact factor: 6.514

2.  Screening of phthalate esters in 47 branded perfumes.

Authors:  Iman Al-Saleh; Rola Elkhatib
Journal:  Environ Sci Pollut Res Int       Date:  2015-08-28       Impact factor: 4.223

3.  Sex differences in the association of urinary bisphenol-A concentration with selected indices of glucose homeostasis among U.S. adults.

Authors:  Hind A Beydoun; Suraj Khanal; Alan B Zonderman; May A Beydoun
Journal:  Ann Epidemiol       Date:  2013-08-16       Impact factor: 3.797

4.  Association of self-reported personal care product use with blood glucose levels measured during pregnancy among women from a fertility clinic.

Authors:  Andrea Bellavia; Lidia Mínguez-Alarcón; Jennifer B Ford; Myra Keller; John Petrozza; Paige L Williams; Russ Hauser; Tamarra James-Todd
Journal:  Sci Total Environ       Date:  2019-08-09       Impact factor: 7.963

Review 5.  Endocrine disruptors and the breast: early life effects and later life disease.

Authors:  Madisa B Macon; Suzanne E Fenton
Journal:  J Mammary Gland Biol Neoplasia       Date:  2013-02-17       Impact factor: 2.673

6.  The effects of di-2-ethylhexyl phthalate on testicular ultrastructure and hormone-regulated gene expression in male rats.

Authors:  Xiaoyun Qin; Quan Ma; Jianhui Yuan; Xinnan Hu; Qin Tan; Zena Zhang; Li Wang; Xinyun Xu
Journal:  Toxicol Res (Camb)       Date:  2018-02-02       Impact factor: 3.524

7.  Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors.

Authors:  Tamarra M James-Todd; John D Meeker; Tianyi Huang; Russ Hauser; Kelly K Ferguson; Janet W Rich-Edwards; Thomas F McElrath; Ellen W Seely
Journal:  Environ Int       Date:  2016-09-17       Impact factor: 9.621

8.  Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway.

Authors:  Wei Wang; Zelieann R Craig; Mallikarjuna S Basavarajappa; Rupesh K Gupta; Jodi A Flaws
Journal:  Toxicol Appl Pharmacol       Date:  2011-11-23       Impact factor: 4.219

Review 9.  The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders.

Authors:  Milica Medic Stojanoska; Natasa Milosevic; Natasa Milic; Ludovico Abenavoli
Journal:  Endocrine       Date:  2016-11-07       Impact factor: 3.633

Review 10.  Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain.

Authors:  Meghan E Rebuli; Heather B Patisaul
Journal:  J Steroid Biochem Mol Biol       Date:  2015-08-22       Impact factor: 4.292

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