Literature DB >> 21155394

2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: a Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis.

S Das1, U Das, B Bandy, D K J Gorecki, J R Dimmock.   

Abstract

2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.

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Year:  2010        PMID： 21155394      PMCID： PMC3346744     

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  7 in total

1.  Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents.

Authors:  Jayendra Patole; Dipti Shingnapurkar; Subhash Padhye; Colin Ratledge
Journal:  Bioorg Med Chem Lett       Date:  2006-01-18       Impact factor: 2.823

2.  Preclinical testing of new drugs for tuberculosis: current challenges.

Authors:  Anne J Lenaerts; Mary Ann Degroote; Ian M Orme
Journal:  Trends Microbiol       Date:  2008-01-07       Impact factor: 17.079

3.  Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

Authors:  A J Kowaltowski; R F Castilho; M T Grijalba; E J Bechara; A E Vercesi
Journal:  J Biol Chem       Date:  1996-02-09       Impact factor: 5.157

4.  Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.

Authors:  L Collins; S G Franzblau
Journal:  Antimicrob Agents Chemother       Date:  1997-05       Impact factor: 5.191

5.  Antimycobacterial arylidenecyclohexanones and related Mannich bases.

Authors:  J R Dimmock; N M Kandepu; U Das; G A Zello; K H Nienaber
Journal:  Pharmazie       Date:  2004-07       Impact factor: 1.267

6.  Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility.

Authors:  R C Goldman; B E Laughon; R C Reynolds; J A Secrist; J A Maddry; M-A Guié; A C Poffenberger; C A Kwong; S Ananthan
Journal:  Infect Disord Drug Targets       Date:  2007-06

7.  Effect of 4-dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen-3-one hydrochloride and related compounds on respiration in rat liver mitochondria.

Authors:  N W Hamon; D L Kirkpatrick; E W Chow; J R Dimmock
Journal:  J Pharm Sci       Date:  1982-01       Impact factor: 3.534
  7 in total
  2 in total

Review 1.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

Review 2.  Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs).

Authors:  Dinesh Shetty; Yong Joon Kim; Hyunsuk Shim; James P Snyder
Journal:  Molecules       Date:  2014-12-24       Impact factor: 4.411
  2 in total

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