BACKGROUND: We examined the clinicopathologic features of papillary thyroid microcarcinomas (PTMCs) measuring≤7 mm and compared them with those of PTMCs>7 mm. METHODS: Between January 2007 and June 2009, a total of 275 patients with PTMCs underwent surgery. They were divided into two groups. Group I included patients with tumors≤7 mm, and group II included those with tumors>7 mm but ≤10 mm. We compared the two groups' clinicopathologic features. RESULTS: Total thyroidectomy was more often performed in group II (p=0.003). Central lymph node metastases were identified in 30.6% of the patients in group I and in 47.8% of the patients in group II (p=0.005). A statistically significant difference between the two groups was also found for capsule invasion (p<0.0001), extrathyroidal extension (p=0.005), and lymphovascular invasion (p=0.025). On the multivariate analysis, central lymph node metastasis was the only independent factor associated with tumor size. CONCLUSION: A PTMC≤7 mm is less likely to have aggressive features, including central lymph node metastasis, capsule invasion, extrathyroidal extension, and lymphovascular invasion, than a PTMC>7 mm. Because the aggressiveness of PTMC was found mainly in the patients with tumors >7 mm, we think that a cutoff value of 7 mm may be considered the threshold of aggressiveness of PTMCs.
BACKGROUND: We examined the clinicopathologic features of papillary thyroid microcarcinomas (PTMCs) measuring≤7 mm and compared them with those of PTMCs>7 mm. METHODS: Between January 2007 and June 2009, a total of 275 patients with PTMCs underwent surgery. They were divided into two groups. Group I included patients with tumors≤7 mm, and group II included those with tumors>7 mm but ≤10 mm. We compared the two groups' clinicopathologic features. RESULTS: Total thyroidectomy was more often performed in group II (p=0.003). Central lymph node metastases were identified in 30.6% of the patients in group I and in 47.8% of the patients in group II (p=0.005). A statistically significant difference between the two groups was also found for capsule invasion (p<0.0001), extrathyroidal extension (p=0.005), and lymphovascular invasion (p=0.025). On the multivariate analysis, central lymph node metastasis was the only independent factor associated with tumor size. CONCLUSION: A PTMC≤7 mm is less likely to have aggressive features, including central lymph node metastasis, capsule invasion, extrathyroidal extension, and lymphovascular invasion, than a PTMC>7 mm. Because the aggressiveness of PTMC was found mainly in the patients with tumors >7 mm, we think that a cutoff value of 7 mm may be considered the threshold of aggressiveness of PTMCs.
Authors: Ian D Hay; Maeve E Hutchinson; Tomas Gonzalez-Losada; Bryan McIver; Megan E Reinalda; Clive S Grant; Geoffrey B Thompson; Thomas J Sebo; John R Goellner Journal: Surgery Date: 2008-12 Impact factor: 3.982
Authors: E Baudin; J P Travagli; J Ropers; F Mancusi; G Bruno-Bossio; B Caillou; A F Cailleux; J D Lumbroso; C Parmentier; M Schlumberger Journal: Cancer Date: 1998-08-01 Impact factor: 6.860
Authors: Nimmi Arora; Harma K Turbendian; Meredith A Kato; Tracy A Moo; Rasa Zarnegar; Thomas J Fahey Journal: Thyroid Date: 2009-05 Impact factor: 6.568
Authors: Elio Roti; Roberta Rossi; Giorgio Trasforini; Fiorenza Bertelli; Maria Rosaria Ambrosio; Luciano Busutti; Elizabeth N Pearce; Lewis E Braverman; Ettore C Degli Uberti Journal: J Clin Endocrinol Metab Date: 2006-02-14 Impact factor: 5.958
Authors: Paolo Miccoli; Michele N Minuto; Clara Ugolini; Erica Panicucci; Piero Berti; Marco Massi; Fulvio Basolo Journal: World J Surg Date: 2007-05 Impact factor: 3.352
Authors: Juan J Sancho; Thomas W Jay Lennard; Ivan Paunovic; Frédéric Triponez; Antonio Sitges-Serra Journal: Langenbecks Arch Surg Date: 2013-12-19 Impact factor: 3.445
Authors: Henning Dralle; Thomas J Musholt; Jochen Schabram; Thomas Steinmüller; Andreja Frilling; Dietmar Simon; Peter E Goretzki; Bruno Niederle; Christian Scheuba; Thomas Clerici; Michael Hermann; Jochen Kußmann; Kerstin Lorenz; Christoph Nies; Peter Schabram; Arnold Trupka; Andreas Zielke; Wolfram Karges; Markus Luster; Kurt W Schmid; Dirk Vordermark; Hans-Joachim Schmoll; Reinhard Mühlenberg; Otmar Schober; Harald Rimmele; Andreas Machens Journal: Langenbecks Arch Surg Date: 2013-03-03 Impact factor: 3.445