Dequan Xu1, Xiaoying Lv1, Song Wang1, Wenjie Dai1. 1. Department of General Surgery, The First Affiliated Hospital of Harbin Medical University Harbin, China.
Abstract
OBJECTIVES: We aimed to determine the predictive factors for central compartment lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC). The outcome of the current study could assist greatly in decision-making regarding further treatment. METHODS: Retrospective analysis of PTMC treated at the First Affiliated Hospital of Harbin Medical University. The predictive risk factors for central lymph node metastases (CLNM) were analyzed with respect to age, sex, tumor size, multifocal and capsular affection. RESULTS: CLNM are common in thyroid microcarcinoma patients. The factors correlated with neoplasm size greater than 5 mm (odds ratio, 0.520; P = 0.001), tumor bilateral (odds ratio, 0.342; P = 0.020), and capsule invasion (odds ratio, 2.539; P = 0.000) were independently predictive of CLNM. In patients with a solitary primary tumor, tumor location in the lower third of the thyroid lobe was associated with a higher risk of CLNM. CONCLUSIONS: The risk factors such as male gender, tumor size > 5 mm, bilateral, multifocal location, lower third of the thyroid lobe and capsule invasion that can be identified preoperatively or intraoperatively, be considered for determination of prophylactic CLND in patients with PTMC.
OBJECTIVES: We aimed to determine the predictive factors for central compartment lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC). The outcome of the current study could assist greatly in decision-making regarding further treatment. METHODS: Retrospective analysis of PTMC treated at the First Affiliated Hospital of Harbin Medical University. The predictive risk factors for central lymph node metastases (CLNM) were analyzed with respect to age, sex, tumor size, multifocal and capsular affection. RESULTS: CLNM are common in thyroid microcarcinomapatients. The factors correlated with neoplasm size greater than 5 mm (odds ratio, 0.520; P = 0.001), tumor bilateral (odds ratio, 0.342; P = 0.020), and capsule invasion (odds ratio, 2.539; P = 0.000) were independently predictive of CLNM. In patients with a solitary primary tumor, tumor location in the lower third of the thyroid lobe was associated with a higher risk of CLNM. CONCLUSIONS: The risk factors such as male gender, tumor size > 5 mm, bilateral, multifocal location, lower third of the thyroid lobe and capsule invasion that can be identified preoperatively or intraoperatively, be considered for determination of prophylactic CLND in patients with PTMC.
Authors: Tracy-Ann S Moo; Ben Umunna; Meredith Kato; Daniel Butriago; Anna Kundel; James A Lee; Rasa Zarnegar; Thomas J Fahey Journal: Ann Surg Date: 2009-09 Impact factor: 12.969
Authors: Ian D Hay; Maeve E Hutchinson; Tomas Gonzalez-Losada; Bryan McIver; Megan E Reinalda; Clive S Grant; Geoffrey B Thompson; Thomas J Sebo; John R Goellner Journal: Surgery Date: 2008-12 Impact factor: 3.982
Authors: William D T Kent; Stephen F Hall; Phillip A Isotalo; Robyn L Houlden; Ralph L George; Patti A Groome Journal: CMAJ Date: 2007-11-20 Impact factor: 8.262
Authors: Jin Young Kwak; Eun-Kyung Kim; Min Jung Kim; Eun Ju Son; Woong Youn Chung; Cheong Soo Park; Kee-Hyun Nam Journal: Ann Surg Oncol Date: 2009-02-18 Impact factor: 5.344